Right ventricular and cyclic guanosine monophosphate signalling abnormalities in stages B and C of heart failure with preserved ejection fraction. [PDF]
ESC Heart Fail, 2021 Petit T +13 more
europepmc +1 more source
Molecular mechanisms of plant NLR activation and signalling
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta +3 more
wiley +1 more source
Shunxin decoction improves diastolic function in rats with heart failure with preserved ejection fraction induced by abdominal aorta constriction through cyclic guanosine monophosphate-dependent protein kinase Signaling Pathway. [PDF]
J Tradit Chin Med, 2022 Jiaying Z +14 more
europepmc +1 more source
Experimental Physiology, Volume 111, Issue 2, Page 474-488, 1 February 2026.Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber +10 more
wiley +1 more source
Ajuga bracteosa Exerts Antihypertensive Activity in l-NAME-Induced Hypertension Possibly through Modulation of Oxidative Stress, Proinflammatory Cytokines, and the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway. [PDF]
ACS Omega, 2022 Shaukat B +7 more
europepmc +1 more source
ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes [PDF]
, 2015 Cleasby, M E
core +2 more sources
hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li +8 more
wiley +1 more source
Determination and quantification of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by HILIC SPE in combination with LC-MS/MS [PDF]
, 2012 Lynen, Frederic +3 more
core +3 more sources
Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3',5'-Monophosphate Signaling Pathway. [PDF]
J Clin Med, 2022 Karna KK +4 more
europepmc +1 more source
Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa +5 more
wiley +1 more source