Results 81 to 90 of about 3,700,789 (338)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Dynamic behavior and damping capacity of auxetic foam pads [PDF]

, 2006
A novel set of auxetic (negative Poisson's ratio) open cell polyurethane foam has been developed and tested under dynamic loading conditions to assess the viscoelastic response under white noise random excitation and compressive cycling.
Bezazi, A, Bullough, WA, Giacomin, J, Scarpa, F   +3 more
core   +1 more source

Damage Detection of Concrete-Filled Square Steel Tube (CFSST) Column Joints under Cyclic Loading Using Piezoceramic Transducers

Italian National Conference on Sensors, 2018
Concrete-filled square steel tube column (CFSSTC) joints are the most important parts of concrete-filled steel tube frame structures. It is of great significance to study the damage of CFSSTC joints under the seismic loads.
Juan Zhang, Jindong Xu, Wenqiang Guan, Guofeng Du   +3 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Mixed-mode cyclic debonding of adhesively bonded composite joints [PDF]

A combined experimental-analytical investigation to characterize the cyclic failure mechanism of a simple composite-to-composite bonded joint is conducted.
Mall, S., Rezaizadeh, M. A.
core   +1 more source

Linear matching method on the evaluation of cyclic behaviour with creep effect [PDF]

, 2012
This paper describes a new Linear Matching Method (LMM) technique for the direct evaluation of cyclic behaviour with creep effects of structures subjected to a general load condition in the steady cyclic state.
Chen, Haofeng, Chen, Weihang, Ure, James Michael   +2 more
core  

Rigid pile response to cyclic lateral loading: laboratory tests

Geotechnique, 2019
This paper presents experimental work aimed at improving understanding of the behaviour of rigid monopiles, in cohesionless soils, subjected to lateral cyclic loading.
C. Abadie, B. Byrne, G. Houlsby
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Influence of Cyclic Loading on the Mechanical Properties of Well Cement

Energies
The cyclic loading generated by injection and production operations in underground gas storage facilities can lead to fatigue damage to cement sheaths and compromise the integrity of wellbores.
Zhen Zhang, Zhongtao Yuan, Sutao Ye, Yang Li, Lvchao Yang, Xueyu Pang, Kaihe Lv, Jinsheng Sun   +7 more
doaj   +1 more source

Behavior of confined granular beds under cyclic thermal loading

, 2019
We investigate the mechanical behavior of a confined granular packing of irregular polyhedral particles under repeated heating and cooling cycles by means of numerical simulations with the Non-Smooth Contact Dynamics method.
Giacomazzi, Elena, Haselbacher, Andreas, Herrmann, Hans J., Iliev, Pavel S., Mendoza, Miller, Wittel, Falk K.   +5 more
core   +1 more source