Results 41 to 50 of about 61,392 (298)

Mechanical characteristics of saturated soils under thermo-cyclic loads

Yantu gongcheng xuebao, 2018
The impact of temperature on the large deformation of nuclear waste disposal, geothermal extraction and storage under cyclic load is should be considered.
ZHANG Sheng 1, 2, LIU Xue-qing 1, 2, XU Shuo 3, XIONG Yong-lin 4, ZHANG Feng 5
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cyclic liquefaction behavior of silty sand considering initial static shear effect: a DEM investigation

Yantu gongcheng xuebao
To gain more insights into the microscopic mechanism of the liquefaction behavior, the particle flow program PFC3D is used to simulate the liquefaction process of silty sands under undrained cyclic loading.
PAN Kun 1 , LI Peipei 1, CAO Yi 2, WU Qixin 3, YANG Zhongxuan 4
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Monotonic, unidirectional, and bidirectional cyclic simple shear responses of municipal solid waste incineration bottom ash

Journal of Rock Mechanics and Geotechnical Engineering
Incineration bottom ash (IBA) holds attractive potential as a construction material, yet its shear behavior under cyclic loading remains insufficiently understood. This study comprehensively characterizes the monotonic and cyclic simple shear behavior of
Zhibo Zhang, Zhanbo Cheng, Xunchang Fei, Xueyu Geng, Kangda Wang, Ziwen Yuan, Zihou Liu, Wei Wu   +7 more
doaj   +1 more source

Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein

mBio, 2023
In bacteria, the most prevalent receptor proteins of 3′,5′-cyclic AMP (cAMP) and 3′,5′-cyclic GMP (cGMP) are found among transcription factors of the Crp-Fnr superfamily.
Laura Werel, Neda Farmani, Elizaveta Krol, Javier Serrania, Lars-Oliver Essen, Anke Becker   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Data to accompany "LESA cyclic ion mobility mass spectrometry of intact proteins from thin tissue sections"

, 2020
Data to accompany "LESA cyclic ion mobility mass spectrometry of intact proteins from thin tissue ...
Cooper, Helen
core   +1 more source

Discerning ambiguous internal fragment assignments that are generated in top-down mass spectrometry with cyclic ion-mobility enhances protein sequence information

, 2023
Top-down mass spectrometry (TD-MS) has become a central technique for the analysis of intact proteins, and internal fragments (fragments containing neither the C- nor N-terminus) have been utilized to enhance the sequence information extracted from such ...
Muhammad, Zenaidee, Gene, Hart-Smith, Luke, Carroll, Tyren, Dodgen   +3 more
core   +1 more source

Effect of particle shape on liquefaction and Re-liquefaction strength of short fiber-reinforced sand

Results in Engineering
Fiber-reinforcement is a widely studied soil stabilization technique, yet certain aspects of its reinforcing mechanisms and fiber-soil interactions remain unexplored.
Takayuki Sakai, Masaki Nakano, Jakhongirbek Ganiev   +2 more
doaj   +1 more source