Results 61 to 70 of about 179,788 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Efficiency at maximum power: An analytically solvable model for stochastic heat engines

, 2007
We study a class of cyclic Brownian heat engines in the framework of finite-time thermodynamics. For infinitely long cycle times, the engine works at the Carnot efficiency limit producing, however, zero power. For the efficiency at maximum power, we find
Feynman R. P., Kulic I. M., Sokolov I. M., T. Schmiedl, U. Seifert, van den Broeck C., Velasco S.   +6 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effects of cationic antimicrobial peptides on liquid-preserved boar spermatozoa. [PDF]

PLoS ONE, 2014
Antibiotics are mandatory additives in semen extenders to control bacterial contamination. The worldwide increase in resistance to conventional antibiotics requires the search for alternatives not only for animal artificial insemination industries, but ...
Martin Schulze, Christof Junkes, Peter Mueller, Stephanie Speck, Karin Ruediger, Margitta Dathe, Karin Mueller   +6 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Development of a Molecular-Imprinted-Polymer based sensor for the electrochemical determination of Triacetone Triperoxide (TATP) [PDF]

, 2014
.The explosive triacetone triperoxide (TATP), which can be prepared from commercially readily available reagents following an easy synthetic procedure, is one of the most common components of improvised explosive devices (IEDs).
Ansari, Belluck, Burks, Buttigieg, Jose Gonzalez-Rodriguez, Kende, Laine, Li, Lin, Lubczyk, Lubczyk, Oxley, Riskin, Samuel Mamo, Schulte-Ladbeck, Sharma, Walter, Widmer, Xie, Yan   +19 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Mobility restrictions in response to local epidemic outbreaks in rock-paper-scissors models

Journal of Physics: Complexity
We study a three-species cyclic model whose organisms are vulnerable to contamination with an infectious disease which propagates person-to-person. We consider that individuals of one species perform a self-preservation strategy by reducing the mobility ...
J Menezes
doaj   +1 more source

New analytical equations for productivity estimation of the cyclic CO2-assisted steam stimulation process considering the non-Newtonian percolation characteristics

Journal of Petroleum Exploration and Production Technology, 2018
The research course in the estimation of productivity of cyclic steam stimulation wells can be divided into three stages: (a) the mobility of heavy oil in the cold area is neglected, (b) the mobility of heavy oil in the cold area is considered—however ...
Fengrui Sun, Yuedong Yao, Guozhen Li
doaj   +1 more source

Strain Space Plasticity Model for Cyclic Mobility

Soils and Foundations, 1992
ABSTRACT The cyclic mobility model proposed in this paper is of a generalized plasticity—multiple mechanism type. The salient feature of the present approach is that the concept of the multiple mechanism, within the framework of plasticity theory defined in strain space, is used as a vehicle for decomposing the complex mechanism into a set of one ...
Susumu Iai, Yasuo Matsunaga, Tomohiro Kameoka   +2 more
openaire   +2 more sources