Results 71 to 80 of about 61,392 (298)

Accurate Collisional Cross Section Measurement by Multi-pass Cyclic Ion Mobility Spectrometry

Ion mobility-mass spectrometry (IM-MS) is a powerful analytical tool for structural characterization. IM measurement provides collision cross section (CCS) values that facilitate analyte identification.
Chaoshuang, Xia, Catherine, Costello, Cheng, Lin, Joseph, Zaia, Elias, Mernie   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Enhancing isomer specificity in mass spectrometry by combining silver ion adduction and ion mobility

Talanta Open
Background: Identification and characterization of steroids from complex mixtures with isomeric precision is key to studying endocrine-related metabolism and disorders.
Varun V. Sharma, Danjo De Chavez, Susan E. Slade, Ingela Lanekoff   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effects of cationic antimicrobial peptides on liquid-preserved boar spermatozoa. [PDF]

PLoS ONE, 2014
Antibiotics are mandatory additives in semen extenders to control bacterial contamination. The worldwide increase in resistance to conventional antibiotics requires the search for alternatives not only for animal artificial insemination industries, but ...
Martin Schulze, Christof Junkes, Peter Mueller, Stephanie Speck, Karin Ruediger, Margitta Dathe, Karin Mueller   +6 more
doaj   +1 more source

Worker-Job Matches, Job Mobility, and Real Wage Cyclicality [PDF]

SSRN Electronic Journal, 2003
Using the British New Earnings Survey Panel Data (NESPD), this paper examines male and female real wage cyclicality over the period 1975–2001. Estimation is undertaken separately for job stayers and job movers. ‘Stayers’ are defined with respect to single jobs within the company, while ‘movers’ refers to individuals changing jobs both within and ...
openaire   +4 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Generalized shear strain-based model for development of excess pore water pressure in saturated sand under anisotropic consolidation

Yantu gongcheng xuebao
The development pattern of the excess pore water pressure in saturated sand under anisotropic consolidation conditions is crucial for understanding the liquefaction behavior of sand.
ZHAO Futang, WU Qixin, ZHENG Junjie, ZHENG Yewei
doaj   +1 more source

New analytical equations for productivity estimation of the cyclic CO2-assisted steam stimulation process considering the non-Newtonian percolation characteristics

Journal of Petroleum Exploration and Production Technology, 2018
The research course in the estimation of productivity of cyclic steam stimulation wells can be divided into three stages: (a) the mobility of heavy oil in the cold area is neglected, (b) the mobility of heavy oil in the cold area is considered—however ...
Fengrui Sun, Yuedong Yao, Guozhen Li
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source