Results 11 to 20 of about 242,009 (329)

CRISPR antiphage defence mediated by the cyclic nucleotide-binding membrane protein Csx23. [PDF]

Nucleic Acids Res
Grüschow S, McQuarrie S, Ackermann K, McMahon S, Bode BE, Gloster TM, White MF.   +6 more
europepmc   +3 more sources

Similar Binding Modes of cGMP Analogues Limit Selectivity in Modulating Retinal CNG Channels via the Cyclic Nucleotide-Binding Domain. [PDF]

ACS Chem Neurosci
Pliushcheuskaya P, Kesh S, Kaufmann E, Wucherpfennig S, Schwede F, Künze G, Nache V.   +6 more
europepmc   +3 more sources

Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]

, 2001
Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz, B Majorovits, D Lal, FT Avignone, G Heusser, HV Klapdor-Kleingrothaus, HV Klapdor-Kleingrothaus, HV Klapdor-Kleingrothaus, HV Klapdor-Kleingrothaus, HV Klapdor-Kleingrothaus, J Ellis, J Hellmig, JD Lewin, K Preese, L Baudis, L Baudis, OA Ponkratenko, P Belli, R Bernabei, R Gaitskell, R Schnee, v Bednyakov, WN Hess   +22 more
core   +2 more sources

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. [PDF]

PLoS ONE, 2013
Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest.
Chai Ann Ng, Ying Ke, Matthew D Perry, Peter S Tan, Adam P Hill, Jamie I Vandenberg   +5 more
doaj   +1 more source

Damage Signaling by Extracellular Nucleotides: A Role for Cyclic Nucleotides in Elevating Cytosolic Free Calcium?

Frontiers in Plant Science, 2021
Extracellular ATP (eATP) is now held to be a constitutive damage-associated molecular pattern (DAMP) that is released by wounding, herbivory or pathogen attack.
Jian Sun, Jian Sun, Youzheng Ning, Limin Wang, Katie A. Wilkins, Julia M. Davies   +5 more
doaj   +1 more source

Control of the Nucleotide Cycle in Photoreceptor Cell Extracts by Retinal Degeneration Protein 3

Frontiers in Molecular Neuroscience, 2018
Retinal degeneration protein 3 (RD3) is crucial for photoreceptor cell survival and linked to Leber Congenital Amaurosis type 12 (LCA12), a hereditary retinal disease in humans.
Hanna Wimberg, Ulrike Janssen-Bienhold, Karl-Wilhelm Koch   +2 more
doaj   +1 more source

Phosphodiesterase 10A (PDE10A): Regulator of Dopamine Agonist-Induced Gene Expression in the Striatum

Cells, 2022
Dopamine and other neurotransmitters have the potential to induce neuroplasticity in the striatum via gene regulation. Dopamine receptor-mediated gene regulation relies on second messenger cascades that involve cyclic nucleotides to relay signaling from ...
Ryan Bonate, Gabriela Kurek, Michael Hrabak, Santanna Patterson, Fernando Padovan-Neto, Anthony R. West, Heinz Steiner   +6 more
doaj   +1 more source

Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes

BMC Bioinformatics, 2005
Background Cyclic nucleotides are ubiquitous intracellular messengers. Until recently, the roles of cyclic nucleotides in plant cells have proven difficult to uncover.
Moorhead Greg BG, Fraser Marie E, Bridges Dave   +2 more
doaj   +1 more source

Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis

Cells, 2021
Exchange proteins directly activated by cAMP (EPAC1 and EPAC2) are one of the several families of cellular effectors of the prototypical second messenger cAMP.
Zhuofu Ni, Xiaodong Cheng
doaj   +1 more source

MODULATION OF THE CGMP-GATED CHANNEL BY CALCIUM [PDF]

, 1995
Calcium acting through calmodulin has been shown to regulate the affinity of cyclic nucleotide-gated channels expressed in cell lines.
LAGNADO, L, SAGOO, MS
core   +1 more source