The arabidopsis cyclic nucleotide interactome [PDF]
Cell Communication and Signaling, 2016 Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-dependent signaling mechanisms in plants since the ...
L. Donaldson, S. Meier, C. Gehring
semanticscholar +6 more sources
Discrimination between cyclic nucleotides in a cyclic nucleotide-gated ion channel. [PDF]
Nat Struct Mol Biol, 2023 Cyclic nucleotide-gated ion channels are crucial in many physiological processes such as vision and pacemaking in the heart. SthK is a prokaryotic homolog with high sequence and structure similarities to hyperpolarization-activated and cyclic nucleotide-modulated and cyclic nucleotide-gated channels, especially at the level of the cyclic nucleotide ...
Pan Y +6 more
europepmc +4 more sources
Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. [PDF]
PLoS ONE, 2011 Cyclic GMP-dependent protein kinases (PKGs) are central mediators of the NO-cGMP signaling pathway and phosphorylate downstream substrates that are crucial for regulating smooth muscle tone, platelet activation, nociception and memory formation.
Jeong Joo Kim +10 more
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Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance. [PDF]
PLoS ONE, 2017 Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels control cardiac and neuronal rhythmicity. HCN channels contain cyclic nucleotide-binding domain (CNBD) in their C-terminal region linked to the pore-forming transmembrane segment with
Sebastien Hayoz +4 more
doaj +1 more source
Structure of the SthK carboxy-terminal region reveals a gating mechanism for cyclic nucleotide-modulated ion channels. [PDF]
PLoS ONE, 2015 Cyclic nucleotide-sensitive ion channels are molecular pores that open in response to cAMP or cGMP, which are universal second messengers. Binding of a cyclic nucleotide to the carboxyterminal cyclic nucleotide binding domain (CNBD) of these channels is ...
Divya Kesters +8 more
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Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
core +2 more sources
C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels. [PDF]
PLoS ONE, 2013 Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest.
Chai Ann Ng +5 more
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Plant Cyclic Nucleotide-Gated Channels: New Insights on Their Functions and Regulation1[OPEN]
Plant Physiology, 2020 Recent advances of plant cyclic nucleotide-gated channels give new insight into their molecular functions focusing on regulation, subunit assembly, and phosphorylation.
P. Dietrich, W. Moeder, K. Yoshioka
semanticscholar +1 more source
Frontiers in Plant Science, 2021 Extracellular ATP (eATP) is now held to be a constitutive damage-associated molecular pattern (DAMP) that is released by wounding, herbivory or pathogen attack.
Jian Sun +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate the primary electrical signals underlying mammalian phototransduction, olfaction, and cardiac pacemaking.
Eric G. B. Evans +4 more
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