Results 301 to 310 of about 1,721,329 (334)
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Cyclic Peptide-Based and Cyclic Peptide–Polymer-Based Nanotubes
2021Rationally designed cyclic peptides (CPs), if composed of even numbers (e.g., 4, 6, 8, 10, or 12) of alternating d- and l-amino acid residues, could stack one another to appear as nanotube structures through self-assembly. The critical interaction to stabilize the nanotubes is an adjacent β-sheet-like intermolecular hydrogen bonding between ring-shaped
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Fragmentation of biotinylated cyclic peptides
Rapid Communications in Mass Spectrometry, 2004Abstract Electrospray ionization coupled with tandem mass spectrometry (MS/MS) was used to determine the preferred binding site(s) of biotin NHS ester with a series of cyclic peptides with antibiotic properties.
Michael E, Lassman +2 more
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Cyclic, modified and conjegated peptides
1993The subject matter for this Chapter has again been allocated sub-headings that reflect main subject areas under which a reasonable number of publications have been cited. In the absence of a detailed keyword index, the sub-headings also provide continuity from previous volumes, so that searching the...
J. S. Davies, John S. Davies
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Synthesis of Cyclic Endiamino Peptides
Journal of the American Chemical Society, 2005Several building blocks for endiamino peptides, as well as several cyclic endiamino peptides themselves, and pyrazin-6-one, which embodies the endiamino group, were prepared. The variety of synthesized compounds shows the potential of this synthesis in the preparation of many different groups of compounds.
Doron, Pappo +3 more
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Journal of the American Chemical Society, 2005
Amide bonds -NH-CO- preferentially exist in trans conformations, the cis conformation being thermodynamically unfavored with respect to the trans by about 2 kcal/mol. Yet, the main reason most proteins or peptides cannot be made from cis-peptide plaques only lies in that connecting them into open chains appears to be sterically impracticable.
Romuald, Poteau, Georges, Trinquier
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Amide bonds -NH-CO- preferentially exist in trans conformations, the cis conformation being thermodynamically unfavored with respect to the trans by about 2 kcal/mol. Yet, the main reason most proteins or peptides cannot be made from cis-peptide plaques only lies in that connecting them into open chains appears to be sterically impracticable.
Romuald, Poteau, Georges, Trinquier
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Synthesis of cyclic tryptathionine peptides
International Journal of Peptide and Protein Research, 1987The helicity of the tryptathionine moiety of the phallotoxins has been recognized by comparison with cyclic tryptathionine tripeptides. In order to investigate the influence of the configuration of the component amino acids on the conformation of the cyclic peptides, six analogue thioether tripeptides containing L‐ and D‐alanine and L‐ and D‐cysteine ...
Zanotti, G., Beijer, B., Wieland, T.
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Biopolymers, 1985
AbstractA multistep computational scheme was used to deduce possible conformations for a cyclic antagonist analog of somatostatin that has been reported by Coy and coworkers. An algebraic algorithm was used to find dihedral angles that give cyclic structures, the energy was computed for these structures, the lower‐energy structures were classified into
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AbstractA multistep computational scheme was used to deduce possible conformations for a cyclic antagonist analog of somatostatin that has been reported by Coy and coworkers. An algebraic algorithm was used to find dihedral angles that give cyclic structures, the energy was computed for these structures, the lower‐energy structures were classified into
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Cyclic Peptide Synthesis with Thioacids
Organic Letters, 2010C-Terminal amino acid 9-fluorenylmethylthioesters may be carried through Boc chemistry solution phase peptide synthesis sequences. After insertion of the final residue in the form of an Fmoc carbamate, treatment with piperidine releases a seco-peptide as a C-terminal thioacid that on treatment with Sanger's reagent undergoes cyclization to a cyclic ...
Sasaki, Kaname, Crich, David
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New cyclic peptide proteasome inhibitors
Bioorganic & Medicinal Chemistry Letters, 2009Here we report the study of a new series of vinyl ester cyclopeptide analogues synthesized on the basis of our previous development of a class of cyclopeptides derived from our linear prototype inhibitors. In these compounds, the exocyclic pharmacophoric unit Leu-VE was linked to the gamma-carboxyl group of the glutamic acid residue at the C-terminal ...
BALDISSEROTTO, Anna +3 more
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Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides
ChemBioChem, 2012Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization-free manner. This method relies on the routine procedures of Fmoc solid-phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower ...
Ji-Shen, Zheng +4 more
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