Results 141 to 150 of about 211,010 (331)

Chemoenzymatic tandem cyclization for the facile synthesis of bicyclic peptides

Communications Chemistry
Bicyclic peptides exhibit improved metabolic stabilities and target specificities when compared to their linear or mono-cyclic counterparts; however, efficient and straightforward synthesis remains challenging due to their intricate architectures.
Masakazu Kobayashi, Naho Onozawa, Kenichi Matsuda, Toshiyuki Wakimoto   +3 more
doaj   +1 more source

Cyclic Peptides of Sarcosine. Syntheses and Conformation. [PDF]

, 1975
Kirsten Titlestad, Kirsten Titlestad, A.‐B. Hörnfeldt, S. Liaaen-Jensen, Gustav Schroll, C. Altona   +5 more
openalex   +1 more source

Heterogeneity of Rheumatoid Arthritis–Associated Interstitial Lung Disease by Longitudinal Forced Vital Capacity Trajectory and Associations With Disease Outcomes

Arthritis Care &Research, EarlyView.
Objective We aimed to identify unique disease trajectories within rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) based on longitudinal forced vital capacity (FVC) values and their associated clinical outcomes. Methods We performed a cohort study of RA‐ILD within the Veterans Health Administration from 1999 to 2021.
Bryant R. England, Yangyuna Yang, Punyasha Roul, Tate M. Johnson, Scott M. Matson, Grant W. Cannon, Brian C. Sauer, Jeffrey R. Curtis, Joshua F. Baker, Ted R. Mikuls   +9 more
wiley   +1 more source

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

, 2023
Xingyu Liu, Wei Cai, Nathan Ronceray, Aleksandra Rađenović, Beat Fierz, Jérôme Waser   +5 more
openalex   +1 more source

Click Conjugation of Boron Dipyrromethene (BODIPY) Fluorophores to EGFR-Targeting Linear and Cyclic Peptides [PDF]

, 2021
Tyrslai M. Williams, Nichole E. M. Kaufman, Zehua Zhou, Sitanshu S. Singh, Seetharama D. Jois, M. Graça H. Vicente   +5 more
openalex   +1 more source

Accuracy of Diagnostic Codes and Algorithms Used to Identify Rheumatoid Arthritis and Juvenile Idiopathic Arthritis in Administrative Claims and Electronic Health Records: Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective This systematic review aimed to assess the diagnostic accuracy of algorithms used to identify rheumatoid arthritis and juvenile idiopathic arthritis in electronic health records. Methods We searched Medline, Embase, and Cochrane Central Register for Controlled Trials databases and included studies that validated case definitions against a ...
Constanza Saka‐Herrán, Jessica Bennett, Yara Alkabti, Muhammad Fatir, Barbara Clyne, Caroline McCarthy, Gráinne Tynan, Nikki Dunne, Michelle Flood, Eoghan McCarthy, Frank Moriarty   +10 more
wiley   +1 more source

Investigating the Impact of Hydrophobic Polymer Segments on the Self-Assembly Behavior of Supramolecular Cyclic Peptide Systems via Asymmetric-Flow Field Flow Fractionation

, 2023
Maria Kariuki, Julia Y. Rho, Stephen C. L. Hall, Sébastien Perrier   +3 more
openalex   +1 more source

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Identification of a novel and high-affinity cyclic peptide targeting Keap1 for inflammation treatment by a combined virtual screening strategy

Journal of Enzyme Inhibition and Medicinal Chemistry
Inhibition of the Keap1-Nrf2 protein-protein interaction with cyclic peptides represents an attractive strategy to treat inflammation. However, the cyclic peptides for this inhibition are constrained by their low affinity. In this study, the peptides 1-6
Shenglin Gao, Xiaokai Shi, Shudan Yang, Yuting Wang, Qian Wang, Minyan Yang   +5 more
doaj   +1 more source

073. RHEUMATOID VASCULITIS AND POLYARTERITIS NODOSA: THE ROLE OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES [PDF]

, 2019
Joao Modesto dos Santos, Maria Jesus Igúzquiza, Maria Cristina Caballero Martínez, Julio Pérez Pelegay, P. Fanlo, Javier Agorreta   +5 more
openalex   +1 more source