Results 301 to 310 of about 211,010 (331)
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Orally Absorbed Cyclic Peptides
Chemical Reviews, 2017Peptides and proteins are not orally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts. Polypeptides are generally too large and polar to passively diffuse through lipid membranes, while most known active transport mechanisms facilitate cell uptake of only very small peptides. Systematic evaluations of peptides
Daniel S. Nielsen +5 more
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Journal of the American Chemical Society, 2006
The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Vincent, Aucagne +3 more
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The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56-63%), despite the disruption of internal amide-amide hydrogen bonding in the macrocycles.
Vincent, Aucagne +3 more
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Studies on cyclic peptides. II. Synthesis of cyclic peptides containing sarcosine
Biopolymers, 1975AbstractCyclic peptides containing sarcosine, cyclo‐(Pro‐Sar‐Gly)2, cyclo‐(Sar‐Sar‐Gly)2, cyclo‐(Sar4), and cyclo‐(Sar6) have been synthesized by the cyclization of the p‐nitrophenyl ester of linear peptides. The tert‐butoxycarbonyl group was used as the Nα‐protecting group, which was removed by acid.
T, Sugihara, Y, Imanishi, T, Higashimura
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Self-healing cyclic peptide hydrogels
Journal of Materials Chemistry B, 2023The structural design principles of cyclic peptides-based hydrogels are introduced. The resulting soft materials exhibited self-healing capabilities.
Alfonso Bayón-Fernández +4 more
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Engineering Cyclic Peptide Toxins
2012Peptide-based toxins have attracted much attention in recent years for their exciting potential applications in drug design and development. This interest has arisen because toxins are highly potent and selectively target a range of physiologically important receptors.
Clark, Richard J., Craik, David J.
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International Journal of Peptide and Protein Research, 1977
Synthesis of a cyclohexadepsipeptide corresponding to the sequence of protodestruxin from linear hexapeptides was attempted through five different routes in a conventional method, and three routes afforded the same cyclopeptide. Biological and physicochemical properties of the synthetic peptide were identical to those of natural protodestruxin ...
S, Lee, N, Izumiya
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Synthesis of a cyclohexadepsipeptide corresponding to the sequence of protodestruxin from linear hexapeptides was attempted through five different routes in a conventional method, and three routes afforded the same cyclopeptide. Biological and physicochemical properties of the synthetic peptide were identical to those of natural protodestruxin ...
S, Lee, N, Izumiya
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Cyclic Peptide-Based and Cyclic Peptide–Polymer-Based Nanotubes
2021Rationally designed cyclic peptides (CPs), if composed of even numbers (e.g., 4, 6, 8, 10, or 12) of alternating d- and l-amino acid residues, could stack one another to appear as nanotube structures through self-assembly. The critical interaction to stabilize the nanotubes is an adjacent β-sheet-like intermolecular hydrogen bonding between ring-shaped
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Fragmentation of biotinylated cyclic peptides
Rapid Communications in Mass Spectrometry, 2004Abstract Electrospray ionization coupled with tandem mass spectrometry (MS/MS) was used to determine the preferred binding site(s) of biotin NHS ester with a series of cyclic peptides with antibiotic properties.
Michael E, Lassman +2 more
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Cyclic, modified and conjegated peptides
1993The subject matter for this Chapter has again been allocated sub-headings that reflect main subject areas under which a reasonable number of publications have been cited. In the absence of a detailed keyword index, the sub-headings also provide continuity from previous volumes, so that searching the...
J. S. Davies, John S. Davies
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