Results 231 to 240 of about 504,196 (405)

Genetic variants linked to type 2 diabetes in CDKN1B and TCF7L2 influence survival outcomes in metastatic colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Multiple genetic polymorphisms characteristic of type 2 diabetes (T2D) have been associated with unfavorable prognostic outcomes in individuals with both T2D and metastatic colorectal cancer. This study evaluated the impact of T2D genetic polymorphisms on metastatic colon cancer prognosis in a cohort of non‐diabetic patients.
Raffaella Ruggiero, Alessandro Ottaiano, Madhura Tathode, Roberto Sirica, Annabella Di Mauro, Monica Ianniello, Nadia Petrillo, Massimiliano Berretta, Silvia Zappavigna, Amalia Luce, Michele Caraglia, Giovanni Savarese   +11 more
wiley   +1 more source

Phase I trial of SPH4336, a novel cyclin-dependent kinase 4/6 inhibitor, in patients with advanced solid tumors. [PDF]

Oncologist
Jiang Y, Liang X, Sun ML, Gao G, Gong Y, Li HP, Liu J, Wang YS.   +7 more
europepmc   +1 more source

Cyclin-Dependent Kinase 5 Is Associated with Apoptotic Cell Death during Development and Tissue Remodeling

, 1997
Qi Zhang, Harleen Singh Ahuja, Zahra Zakeri, Debra J. Wolgemuth   +3 more
openalex   +1 more source

Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21 [PDF]

, 1995
Zhen‐Qiang Pan, Joyce T. Reardon, Lei Li, Hernan Flores‐Rozas, Randy J. Legerski, Aziz Sancar, Jerard Hurwitz   +6 more
openalex   +1 more source

Diagnosis and management of gestational trophoblastic disease: 2025 update

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Gestational trophoblastic disease (GTD) arises from abnormal placenta and comprises a spectrum of premalignant to malignant disorders. Changes in the epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway.
Hextan Y. S. Ngan, Michael J. Seckl, Ross S. Berkowitz, Yang Xiang, François Golfier, Paradan K. Sekharan, Antonio Braga, Andrea Garrett   +7 more
wiley   +1 more source

The Cyclin-Dependent Kinase activity modulates the central carbon metabolism in maize during germination. [PDF]

Physiol Plant
Lara-Núñez A, Garza-Aguilar SM, Páez-Franco JC, de Dios Galindo-de-la-Rosa J, Vallejo-Becerra V.   +4 more
europepmc   +1 more source

G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts [PDF]

, 1998
Lisa Connell‐Crowley, Stephen J. Elledge, J. Wade Harper   +2 more
openalex   +1 more source

Current Progress in Targeting Human Cytomegalovirus Infection

iLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Cyclin-Dependent Kinase Inhibitors in the Rare Subtypes of Melanoma Therapy. [PDF]

Molecules
Kaszubski J, Gagat M, Grzanka A, Wawrzyniak A, Niklińska W, Łapot M, Żuryń A.   +6 more
europepmc   +1 more source

Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

, 1998
Robin Fåhræus, Sonia Laı́n, Kathryn L. Ball, David P. Lane   +3 more
openalex   +1 more source