Results 231 to 240 of about 518,198 (339)

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Clinical significance of cyclin-dependent kinase inhibitor 3 in hepatocellular carcinoma. [PDF]

Mol Clin Oncol
Liu X, Chang K, Liu J.
europepmc   +1 more source

Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow

Obesity, EarlyView.
ABSTRACT Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear.
Xu Zhang, Madison L. Doolittle, Ting Fan, Utkarsh Tripathi, Yan Er Ng, Xinyi Jiang, João F. Passos, Diana Jurk, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Sundeep Khosla, Nathan K. LeBrasseur   +13 more
wiley   +1 more source

Efficacy and Predictability of Cyclin-Dependent Kinase 4/6 Inhibitors in HER2-Positive Breast Cancer. [PDF]

Cancers (Basel)
Abbasi MS, Afzal MZ, Sarwar T, Gamlen-Steves HA.   +3 more
europepmc   +1 more source

Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma.

, 2015
由香 石原, ユカ イシハラ, Yuka Ishihara   +2 more
openalex   +1 more source

Coupled Transcriptional and Translational Control of Cyclin-Dependent Kinase Inhibitor p18^INK4cExpression during Myogenesis

, 1998
Dawn E. Phelps, Kuang-Ming Hsiao, Yan Li, Nanpin Hu, David S. Franklin, Eva Westphal, Eva Y.-H. P. Lee, Yue Xiong   +7 more
openalex   +2 more sources

Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death [PDF]

, 2018
Dong Guo, Wenting Xie, Pan Xiong, Huifang Li, Siqi Wang, Guimiao Chen, Yuehong Gao, Jiechao Zhou, Ye Zhang, Guojun Bu, Maoqiang Xue, Jie Zhang   +11 more
openalex   +1 more source

Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Mucosal melanoma (MM) is an extremely aggressive malignant tumor in the head and neck region associated with a poor prognosis. In the present study, we conducted cell proliferation assay and western blotting using cell lines derived from MM and the immunohistochemical analysis of pathological MM tissues to identify novel therapeutic ...
Takayoshi Hattori, Makiko Fujii, Tsutomu Ueda, Akira Ishikawa, Yuichi Mine, Bingwen Xu, Tomoya Suehiro, Minoru Hattori, Hiroaki Tahara, Yuki Sato, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Takashi Ishino, Sachio Takeno   +14 more
wiley   +1 more source

PAK4 phosphorylates cyclin-dependent kinase 2 to promote the G₁/S transition during adipogenesis. [PDF]

Exp Mol Med
Yu HC, Park SH, Jo HJ, Sim H, Lee MR, Kim G, Park SY, Lee Y, Bae EJ, Park BH.   +9 more
europepmc   +1 more source

Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin‐dependent kinase 5 activity [PDF]

, 2015
Xiaolong Liu, Somdeb BoseDasgupta, Rajesh Jayachandran, Vera Studer, Sebastian Rühl, Michael Stieß, Jean Pieters   +6 more
openalex   +1 more source