Results 51 to 60 of about 383,210 (284)

Positional information readout in $Ca^{2+}$ signaling [PDF]

Phys. Rev. Lett. 123, 058102 (2019), 2017
Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
arxiv   +1 more source

A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle

npj Systems Biology and Applications, 2017
Cell cycle control: Order in time achieved by dynamic coupling A dynamic coupling of cyclin-dependent kinase with transcription factors in yeast offers insights into the timely cell cycle progression.
Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis   +10 more
doaj   +1 more source

Reaction Engineering and Comparison of Electroenzymatic and Enzymatic ATP Regeneration Systems [PDF]

arXiv, 2023
Adenosine-5'-triphosphate (ATP) plays a crucial role in many biocatalytic reactions and its regeneration can influence the performance of a related enzymatic reaction significantly. Here, we established an electrochemically coupled ATP regeneration by pyruvate oxidase and acetate kinase (ACK) for the phosphorylation of mevalonate catalyzed by ...
arxiv  

Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains.

ACS Chemical Biology, 2013
Bromodomain-containing proteins are considered atypical kinases, but their potential to interact with kinase inhibitors is unknown. Dinaciclib is a potent inhibitor of cyclin-dependent kinases (CDKs), which recently advanced to Phase III clinical trials ...
Mathew P Martin, S. Olesen, Gunda Ingrid Georg, E. Schönbrunn   +3 more
semanticscholar   +1 more source

The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins

Viruses, 2013
The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics.
Laura Graf, Rike Webel, Sabrina Wagner, Stuart T. Hamilton, William D. Rawlinson, Heinrich Sticht, Manfred Marschall   +6 more
doaj   +1 more source

Foxp3 Protein Stability Is Regulated by Cyclin-dependent Kinase 2*

Journal of Biological Chemistry, 2013
Background: Foxp3 post-translational regulation remains unclear. Results: Foxp3 is phosphorylated by cyclin-dependent kinase 2 (CDK2) and has increased stability and function without its CDK motifs.
P. Morawski, Parul Mehra, Chunxia Chen, T. Bhatti, A. Wells   +4 more
semanticscholar   +1 more source

Deletion of cyclin dependent kinase inhibitor 2a gene as a marker of oropharyngeal carcinomas non-associated with human papillomavirus and its prognostic value

Medičnì Perspektivi
Patients with human papilloma virus associated oropharyngeal squamous cell carcinoma generally have better treatment outcomes and prognosis compared to those with non-papillomavirus-associated oropharyngeal squamous cell carcinoma.
I.S. Shponka, Bondarenko O.O. Bondarenko ч, O.V. Kovtunenko, V.V. Rakhmanov   +3 more
doaj   +1 more source

Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications

Toxicology Reports, 2015
Cell cycle deregulation is common in human hepatocellular carcinoma (HCC). To ensure proper cell cycle controlling, cyclin/cyclin-dependent kinases (CDK) complexes are tightly regulated by CDK inhibitors (CKIs) in normal cells.
Yu-Ting Peng, Wen-Ren Wu, Lih-Ren Chen, Kung-Kai Kuo, Cheng-Hui Tsai, Yu-Ting Huang, Yu-Hsuan Lan, Fang-Rong Chang, Yang-Chang Wu, Yow-Ling Shiue   +9 more
doaj   +1 more source

Inhibition of Mitochondrial Antioxidant Defense and CDK4/6 in Mesothelioma

Molecules, 2023
Advanced mesothelioma is considered an incurable disease and new treatment strategies are needed. Previous studies have demonstrated that mitochondrial antioxidant defense proteins and the cell cycle may contribute to mesothelioma growth, and that the ...
Marian Kratzke, George Scaria, Stephen Porter, Betsy Kren, Mark A. Klein   +4 more
doaj   +1 more source

A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation [PDF]

, 2006
The induction of late long-term potentiation (L-LTP) involves complex interactions among second messenger cascades. To gain insights into these interactions, a mathematical model was developed for L-LTP induction in the CA1 region of the hippocampus. The differential equation-based model represents actions of protein kinase A (PKA), MAP kinase (MAPK ...
arxiv   +1 more source