Results 161 to 170 of about 805,965 (369)

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source

Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4⁺ T cells

Retrovirology, 2006
Background The latent reservoir of human immunodeficiency virus type 1 (HIV-1) in resting CD4+ T cells is a major obstacle to the clearance of infection by highly active antiretroviral therapy (HAART). Recent studies have focused on searches for adjuvant
Rice Andrew P, Sung Tzu-Ling
doaj   +1 more source

KinDEL: DNA-Encoded Library Dataset for Kinase Inhibitors [PDF]

arXiv
DNA-Encoded Libraries (DEL) are combinatorial small molecule libraries that offer an efficient way to characterize diverse chemical spaces. Selection experiments using DELs are pivotal to drug discovery efforts, enabling high-throughput screens for hit finding.
arxiv  

A Protein Encoded by the Latency-Related Gene of Bovine Herpesvirus 1 Is Expressed in Trigeminal Ganglionic Neurons of Latently Infected Cattle and Interacts with Cyclin-Dependent Kinase 2 during Productive Infection [PDF]

, 1998
Yunquan Jiang, Ashfaque Hossain, M. T. C. Winkler, Todd Holt, Alan R. Doster, Clinton Jones   +5 more
openalex   +1 more source

Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells. [PDF]

Biomedicines, 2023
Basappa B, Poonacha LK, Xi Z, Vishwanath D, Yang JR, Nagaraja O, Swamynayaka A, Madegowda M, Chinnathambi A, Alharbi SA, Gurudatt DM, Pandey V, Shivananju N, Ahn KS, Sethi G, Lobie PE, Shubha PB.   +16 more
europepmc   +1 more source

P27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability [PDF]

, 2015
The cyclin-dependent kinase (CDK) inhibitor p27(kip1) is a critical regulator of the G1/S-phase transition of the cell cycle and also regulates microtubule (MT) stability.
Armenia, Joshua, Baldassarre, Gustavo, Belletti, Barbara, Berton, Stefania, Bomben, Riccardo, D'Andrea, Sara, Fabris, Linda, Gattei, Valter, Pellizzari, Ilenia, Philips, Mark R., Schiappacassi, Monica, Segatto, Ilenia, VECCHIONE, ANDREA   +12 more
core   +1 more source

Optimization of a genetically encoded biosensor for cyclin B1-cyclin dependent kinase 1

Mol. BioSyst., 2014
Fluorescent protein (FP)-based biosensors have revolutionized the ability of researchers to monitor enzyme activities in live cells. While the basic design principles for FP-based biosensors are well established, first-generation biosensor constructs typically suffer from relatively low fluorescence responses that limit their general applicability. The
Brittney R. Sell, Robert E. Campbell, Ahmed S.F. Belal, Michael W. Davidson, Hiofan Hoi   +4 more
openaire   +4 more sources

π‐PhenoDrug: A Comprehensive Deep Learning‐Based Pipeline for Phenotypic Drug Screening in High‐Content Analysis

Advanced Intelligent Systems, EarlyView.
This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li, Qinxue Ouyang, Mingfei Han, Xiaoqing Liu, Fuchu He, Yunping Zhu, Ling Leng, Jie Ma   +7 more
wiley   +1 more source

Cks1 Is Required for G₁Cyclin–Cyclin-Dependent Kinase Activity in Budding Yeast [PDF]

, 2000
Gregory J. Reynard, William Reynolds, Rati Verma, Raymond J. Deshaies   +3 more
openalex   +1 more source

Growth Charts for Children With Beckwith–Wiedemann Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Beckwith–Wiedemann spectrum (BWSp) is an overgrowth disorder caused by (epi)genetic alterations in chromosome 11p15. This study aimed to develop BWSp‐specific growth charts and explore genotype/phenotype correlations with respect to growth. Heights, weights, and head circumferences were retrospectively collected from 581 individuals with BWSp ...
Saskia M. Maas, Peter Lauffer, Guido Cocchi, Madison DeMarchis, Andrew M. George, Alessandro Mussa, Francesco Pellegrino, Alexander M. J. Spaans, Emma C. van den Brink, Jan M. Wit, Leonie A. Menke, Jennifer M. Kalish   +11 more
wiley   +1 more source