Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017 Hepatocellular carcinoma is an aggressive neoplasm and is one of the most common human cancers. Recently, long non-coding RNAs have been demonstrated to participate in pathogenesis of many diseases including the progression in several cancers.
C. Dou +5 more
semanticscholar +1 more source
Cyclin-Dependent Kinase 5 Phosphorylates Disabled 1 Independently of Reelin Signaling [PDF]
The Journal of Neuroscience, 2002 Two major signaling pathways that control neuronal positioning during brain development have been uncovered as a result of genetic and biochemical studies on neurological mouse mutants. Mice deficient in Reelin, Disabled 1 (Dab1), or both the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2) exhibit identical ...
Lakhu, Keshvara +3 more
openaire +2 more sources
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. [PDF]
, 2011 Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual ...
Balog, Eva Rose M +8 more
core +2 more sources
Wound Healing Potential of Spirulina Protein on CCD-986sk Cells
Marine Drugs, 2019 Wound healing is a dynamic and complex process. The proliferation and migration of dermal fibroblasts are crucial for wound healing. Recent studies have indicated that the extracts from Spirulina platensis have a positive potential for wound healing ...
Ping Liu +4 more
doaj +1 more source
Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in glioma. [PDF]
, 2011 G2 → M transition is a strategic target for glioma chemotherapy. Key players in G2 → M transition include CDC2 and glycogen synthase kinase 3β (GSK3β), which are highly regulated by posttranslational phosphorylation.
Otero, José Javier, Tihan, Tarik
core +3 more sources
Cyclin-dependent kinases as therapeutic targets for HIV-1 infection [PDF]
Expert Opinion on Therapeutic Targets, 2016 A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1 replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 infection, especially in HIV-1 cure strategies. Current HIV-1 cure strategies involve the development of small molecules that are able to activate HIV-1 from latent infection, thereby ...
openaire +2 more sources
Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways. [PDF]
PLoS ONE, 2018 The present study was designed to investigate the pathways involved in the effect of betel nut arecoline on cell viability in 3T3-L1 preadipocytes. Arecoline, but not arecaidine or guvacine, inhibited preadipocyte viability in a concentration- and time ...
Zi-Han Tian +8 more
doaj +1 more source
Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]
, 2013 Peer reviewedPublisher ...
Martin, Samuel A.M. +3 more
core +2 more sources
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors [PDF]
Proceedings of the National Academy of Sciences, 2001 Cyclin-dependent kinase 5 (Cdk5) is a multifunctional neuronal protein kinase that is required for neurite outgrowth and cortical lamination and that plays an important role in dopaminergic signaling in the neostriatum through phosphorylation of Thr-75 of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, molecular mass 32 kDa ...
F, Liu +8 more
openaire +2 more sources
Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exit.
PLoS ONE, 2007 M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis.
Vincenzo D'Angiolella +4 more
doaj +1 more source