Results 261 to 270 of about 259,012 (283)

Extraneuronal roles of cyclin‐dependent kinase 5

BioEssays, 2006
AbstractCyclin‐dependent kinase 5 (Cdk5) is recognized as an essential molecule in the brain, where it regulates several neuronal activities, including cytoskeletal remodeling and synaptic transmission. While activity of Cdk5 has primarily been associated with neurons, there are now substantial data indicating that the kinase's activity and function ...
Jesusa L, Rosales, Ki-Young, Lee
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Cyclin-dependent kinase-5 targeting for ischaemic stroke

Current Opinion in Pharmacology, 2009
Recovery from ischaemic stroke is dependent on survival of neurones, particularly in peri-infarcted regions. Angiogenesis is critical for the development of new microvessels resulting in the re-formation of collateral circulation associated with enhanced neuronal survival and reduced morbidity and mortality.
Mark, Slevin, Jerzy, Krupinski
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Cyclin-dependent kinase 5 immunoreactivity for granulovacuolar degeneration

NeuroReport, 2012
In addition to senile plaque and neurofibrillary tangles, granulovacuolar degeneration is a hallmark of Alzheimer's disease. A number of tau kinases, such as c-jun N-terminal kinase (JNK), glycogen-synthase kinase-3β (GSK3β), and casein kinase 1 (CK1), have been reported to be markers of granulovacuolar degeneration.
Masahiro, Nakamori, Tetsuya, Takahashi, Yuu, Yamazaki, Takashi, Kurashige, Takemori, Yamawaki, Masayasu, Matsumoto   +5 more
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Cyclin Dependent Kinase 5 (Cdk5)

2008
Neuronsmigrate from proliferative zone to their final position during brain development. Cyclin-dependent kinase 5 (Cdk5) plays an important role in neuronal migration to establish a proper structure of the brain. Analyses of Cdk5/p35-deficient mice have provided the knowledge about the role of Cdk5/p35 in neuronal migration.
Ip, Nancy Yuk-Yu LIFS, Tsai, Li-Huei
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Cyclin-Dependent Kinase 5--A Neuronal Killer?

Science of Aging Knowledge Environment, 2003
In dividing cells, cyclin-dependent kinases (Cdks) are cell cycle-associated protein kinases that regulate proliferation, differentiation, senescence, and apoptosis. In neurons that no longer divide, deregulation of Cdks, especially Cdk5, occurs in many neurological disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD).
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A brain-specific activator of cyclin-dependent kinase 5

Nature, 1994
Phosphorylation of the neurofilament proteins of high and medium relative molecular mass, as well as of the Alzheimer's tau protein, is thought to be catalysed by a protein kinase with Cdc2-like substrate specificity. We have purified a novel Cdc2-like kinase from bovine brain capable of phosphorylating both the neurofilament proteins and tau.
Lew, J., Huang,Q Q., Qi, Robert Zhong, Winkfein, R.J., Aebersold, R., Hunt, T., Wang, J.H.   +6 more
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Cyclin-dependent Kinase 5 and Neurodegenerative Diseases

Molecular Neurobiology
Neurodegenerative diseases are a group of diseases characterized by the progressive loss of neurons, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. These diseases have a high incidence and mortality rate globally, placing a heavy burden on patients and their families.
Mingxue Song, Yalong Qiang, Xiulan Zhao, Fuyong Song   +3 more
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Cyclin-dependent kinases 5 template: Useful for virtual screening

Computers in Biology and Medicine, 2012
The present study reports the development of a template for the active binding site of Cdk5 for structure-based drug design. The developed template of Cdk5 was validated by redocking with ligands I (PBD code 1UNG), II (PBD code 1UNL) and III (PBD code 1UNH).
Siripit, Pitchuanchom, Chantana, Boonyarat, Stefano, Forli, Arthur J, Olson, Chavi, Yenjai   +4 more
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Targeting Cyclin-Dependent Kinase 5 (CDK5) in Glioblastoma

2021
Glioblastoma multiforme (GBM) is the most common brain cancer that develops from the malignant transformation of astrocytes and glial cells. The majority of their tumors occur due to dysregulation of cell cycle related-genes like cyclin-dependent kinases that promote uncontrollable cell proliferation and survival.
Rusia H. Lee, Mauricio Reginato, Todd Strochlic   +2 more
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Modulation of Reelin signaling by Cyclin-dependent kinase 5

Brain Research, 2007
The Reelin signaling and Cyclin-dependent kinase 5 (Cdk5) both regulate neuronal positioning in the developing brain. Using double-transgenic mice, we have previously shown that these two signaling pathways lie in parallel fashion and have a genetic interaction.
Toshio, Ohshima, Hiromi, Suzuki, Toshifumi, Morimura, Masaharu, Ogawa, Katsuhiko, Mikoshiba   +4 more
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