Results 271 to 280 of about 259,012 (283)
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Cyclin-dependent kinase 5 (CDK5) and neuronal cell death
Cell and Tissue Research, 2003Many neurological disorders like Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis (ALS) or stroke have in common a definite loss of CNS neurons due to apoptotic or necrotic neuronal cell death. Previous studies suggested that proapoptotic stimuli may trigger an abortive and, therefore, eventually fatal cell cycle reentry in ...
J H, Weishaupt, C, Neusch, M, Bähr
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Cyclin-Dependent Kinase 5 in Axon Growth and Regeneration
2012Injury to the central nervous system often leads to irreversible deficits because of the failure of damaged axons to regrow and restore the functional neural circuitry. Coordinated orchestration of multiple cellular processes including cytoskeletal dynamics and gene expression are essential for both developmental and regenerative axon growth. Recently,
Ye, Tao LIFS, Fu, Kit Yu, Ip, Nancy Y.
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Cyclin-Dependent Kinase 5 and Insulin Secretion
2008Cyclin-dependent kinase 5 (Cdk5) is emerging as a multifunctional kinase involved in regulating numerous cellular processes. Lately, Cdk5 has also emerged as a key controller of regulated membrane fusion in secretory cells. The pancreatic β-cell is highly specialized to secrete insulin in response to elevated glucose concentrations in the blood.
Christina Bark +4 more
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Role of cyclin-dependent kinase 5 in capsaicin-induced cough
European Journal of Pharmacology, 2007The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner.
Junzo, Kamei +3 more
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Acetylation of cyclin-dependent kinase 5 is mediated by GCN5
Biochemical and Biophysical Research Communications, 2014Cyclin-dependent kinase 5 (CDK5), a member of atypical serine/threonine cyclin-dependent kinase family, plays a crucial role in pathophysiology of neurodegenerative disorders. Its kinase activity and substrate specificity are regulated by several independent pathways including binding with its activator, phosphorylation and S-nitrosylation.
Juhyung, Lee +5 more
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Reelin and Cyclin-Dependent Kinase 5
2008Reelin, an extracellular signaling molecule, and cyclin-dependent kinase 5 (Cdk5), a cytoplasmic kinase, are key regulators of normal brain development, including establishment of the complex brain structure. Recent studies have indicated that both Reelin signaling and Cdk5 are also involved in synaptic plasticity and neurodegeneration. In this chapter,
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Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2000Cyclin-dependent kinase-5 (CDK5) is a serine-threonine protein kinase that has been implicated in a number of physiological processes in nerve and muscle cells, including neurogenesis, neuritic outgrowth, axonal transport of membrane-bound organelles and myogenesis.
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Targeting cyclin dependent kinase 5 in hepatocellular carcinoma
2014For a long time cyclin dependent kinase 5 (Cdk5) was thought to be of exclusive importance in neuronal cells. However, recently increasing evidence suggests a function of Cdk5 in cancer progression. In the present study, we examined the role of Cdk5 in hepatocellular carcinoma (HCC), a highly chemoresistant cancer with poor prognosis.
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Cyclin Dependent Kinase 5 (CDK5) and Neurodegeneration
Clinical Science, 1999N Bajaj +3 more
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