Results 91 to 100 of about 29,685 (221)

Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss

Aging Cell, Volume 25, Issue 2, February 2026.
Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli, Lucía Casares‐Crespo, Elena Juárez‐Escoto, Helena Mira   +3 more
wiley   +1 more source

Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. [PDF]

PLoS ONE, 2011
Hypoxia restricts cell proliferation and cell cycle progression at the G1/S interface but at least a subpopulation of carcinoma cells can escape the restriction.
Heidi Högel, Krista Rantanen, Terhi Jokilehto, Reidar Grenman, Panu M Jaakkola   +4 more
doaj   +1 more source

The Molecular Pathogenesis of Pituitary Adenomas: An Update [PDF]

, 2013
Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development
Jiang, Xiaobing, Zhang, Xun
core   +2 more sources

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression

Journal of Ginseng Research
Background: Hepatic fibrosis (HF) continues to be a significant global health concern, substantially contributing to morbidity and mortality due to the absence of effective therapeutic options.
Kaili Deng, Min Li, Yuanyuan Li, Liangliang Xiang, Yuhua Wang, Hechen Shi, Jiayi Cheng, Sha Huang, Zhiping Lv   +8 more
doaj   +1 more source

Impact of time‐restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high‐fat diet‐induced obesity

The Journal of Physiology, Volume 604, Issue 3, Page 1137-1157, 1 February 2026.
Abstract figure legend A 10 week time‐restricted feeding (TRF) regimen was implemented in aged female mice following 12 weeks of high‐fat diet (HFD) feeding. TRF partially reversed HFD‐induced weight and fat mass gain, reduced adipocyte size and increased size heterogeneity in white adipose tissue.
Theresa Bushman, Hongming Su, Xiaoli Chen   +2 more
wiley   +1 more source

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence [PDF]

, 2016
Additional file 3: Figure S3. Regulation of genes of Arrhythmogenic right ventricular cardiomyopathy pathway during senescence induction in HFF strains Genes of the “Arrhythmogenic right ventricular cardiomyopathy” pathway which are significantly up ...
A Chicas, A Ciccia, A Iglesias-Ara, A Kaneda, A Leonardo Di, A Massoud, A Musio, A Ors, A Poehlmann, A Saadane, A Smogorzewska, A Ventura, A Zuryń, A Zuryń, AA Goodarzi, AB Parrish, AC Baege, AC Johansson, AJ Nakamura, AJT Millis, AM Havelka, AY Maslov, B Cen, B Pandit, B Zhivotovsky, BD Chang, Bernardes Jesus de, BP Kaistha, C Kenyon, C Michaloglou, C Morvan Le, C Rouault, C Sandhu, C Sidler, C Trapnell, CF Winter de, Christoph Kaether, CM Aliouat-Denis, D Bhaumik, D Coppola, D Lodygin, D Muthna, DA Alcorta, DH Lackner, DH Larsen, DJ Baker, DM Finucane, DN Shelton, DR Bentley, DR Wonsey, DW Chan, E Hara, E Natarajan, E Pazolli, EJ Gavin, ES Hwang, F Debacq-Chainiaux, F d’Adda di Fagagna, F Ling, F Rapaport, F Rodier, F Rodier, F Seyednasrollah, FA Mallette, G Thuret, GP Dimri, GP Dimri, GP Dimri, H Harada, H Takai, H Zalzali, HJ Kim, HJ Kim, I Androic, I Ben-Porath, I Ben-Porath, I Wierstra, IB Roninson, IK Yoon, IM Kim, IP Kovalchuk, J Bartkova, J Bunt, J Campisi, J Campisi, J Campisi, J Campisi, J Laoukili, J Manns, J Pawlowski, J Tomida, J Zhao, JC Acosta, JC Jeyapalan, JF Passos, JH Chen, JH Chen, JH Chin, JM Dhahbi, JM Yi, JP Carey, JP Coppé, JR Smith, JW Hofmann, JW Shay, K Itahana, K Johung, K Suzuki, K Voutetakis, KH Choi, KS Kim, L Gopinathan, L Hayflick, L Hirsch, L Jia, L Meng, L Zhang, M Blank, M Braig, M Collado, M Kronschnabl, M Narita, M Petric, M Purcell, M Serrano, MA Bonelli, Marco Groth, Matthias Platzer, MD Robinson, MI Love, MJ Smout, MK Ha, MK Kang, MT Paulsen, N Kikuchi, N Martin, N Ohtani, N Wajapeyee, NF Mathon, NG Berube, O Aksoy, O Toussaint, P Dekker, P Flicek, P Gupta, P Luo, P Sun, Peter Hemmerich, Q Gan, QF Wu, R Binet, R Mirzayans, R Mjelle, R Salama, RA Quadri, Reinhard Guthke, RJ Sabin, RT Abraham, S Anders, S Courtois-Cox, S Ferrando-Martinez, S Gonzalez, S Haupt, S Honda, S Hubackova, S Kim, S Lin, S Marthandan, S Marthandan, S Marthandan, S Marthandan, S Pollok, S Ressler, S Schäuble, S Sivakumar, S Vaughan, S Walter, Shiva Marthandan, SJ Robles, SP Linke, SP Mooijaart, SS Myatt, Steffen Priebe, Stephan Diekmann, T Chen, T Kaneko, T Kidokoro, T Kuilman, TC Kuilman, TV Kalin, U Herbig, Uwe Menzel, V Gire, VV Kalinichenko, W Cosme-Blanco, W Luo, W Wagner, W Xue, XW Cheng, Y Bai, Y Benjamini, Y Chien, Y Kong, Y Kotake, Y Ma, Y Nakayama, Y Takahashi, Y Tan, Y Zhang, YH Hsu, YJ Choi, YM Kim, Z Chen, Z Gong, Z Wang, Z Xie   +215 more
core   +5 more sources

A Survey on Association of P16 Protein and Uterine Cervical Dysplasia

مجله دانشکده پزشکی اصفهان, 2011
Background: Cervical (uterine) carcinoma is the second most frequent type of women cancer. Success in early diagnosis of this disease is due to the use of pap-smear test. However, this test has both false-positive and false-negative results.
Babak Izadi, Sedigheh Khazaei, Sayed Ghasem Mirbahari   +2 more
doaj  

Cyclin-dependent kinase inhibitors [PDF]

, 2009
Stanični ciklus je jedan od najvažnijih procesa koji se događa u stanicama. Omogućuje prenošenje identičnog genetičkog materijala iz generacije u generaciju i osigurava da isti ostane kompletno očuvan.
Jemin, Nikolina
core   +2 more sources

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source