Results 101 to 110 of about 28,797 (249)
Supplementary Figure 1 from The Inhibitor of Cyclin-Dependent Kinase 4a/Alternative Reading Frame (<b><i>INK4a/ARF</i></b>) Locus Encoded Proteins p16<sup>INK4a</sup> and p19<sup>ARF</sup> Repress Cyclin D1 Transcription through Distinct <b><i>cis</i></b> Elements [PDF]
, 2023 Mark D’Amico +9 more
openalex +2 more sources
Chinese Medical Journal. Background:. Senescence significantly participates in shaping the pathobiological process underlying chronic obstructive pulmonary disease (COPD). Currently, the mechanisms underlying the anti-aging effects of hydrogen sulfide (H2S) in COPD are not ...
Sha Liao +10 more
doaj +1 more source
In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells [PDF]
, 2015 Oncogenic signaling in melanocytes results in oncogene-induced senescence (OIS), a stable cell-cycle arrest frequently characterized by a bi- or multinuclear phenotype that is considered as a barrier to cancer progression.
Bröcker, E.-B. +12 more
core +2 more sources
Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao +5 more
wiley +1 more source
Obesity, Volume 34, Issue 3, Page 652-661, March 2026.ABSTRACT Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear.
Xu Zhang +13 more
wiley +1 more source
A Survey on Association of P16 Protein and Uterine Cervical Dysplasia
مجله دانشکده پزشکی اصفهان, 2011 Background: Cervical (uterine) carcinoma is the second most frequent type of women cancer. Success in early diagnosis of this disease is due to the use of pap-smear test. However, this test has both false-positive and false-negative results.
Babak Izadi +2 more
doaj
Cell Cycle Control by Xenopus p28^(Kix1) a Developmentally Regulated Inhibitor of Cyclin-dependent Kinases [PDF]
, 1996 We have isolated Xenopus p28^(Kix1), a member of the p21^(CIP1)/p27^(KIP1)/p57^(KIP2) family of cyclin-dependent kinase (Cdk) inhibitors. Members of this family negatively regulate cell cycle progression in mammalian cells by inhibiting the activities of
Dunphy, William G., Shou, Wenying
core
Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma
Otolaryngology–Head and Neck Surgery, Volume 174, Issue 3, Page 784-791, March 2026.Abstract Objective Mucosal melanoma (MM) is an extremely aggressive malignant tumor in the head and neck region associated with a poor prognosis. In the present study, we conducted cell proliferation assay and western blotting using cell lines derived from MM and the immunohistochemical analysis of pathological MM tissues to identify novel therapeutic ...
Takayoshi Hattori +14 more
wiley +1 more source