Results 151 to 160 of about 16,580 (182)

Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes P16 (MTS1) and P15 (MTS2)

Journal of Molecular Evolution, 1995
Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell contact and transforming growth factor-beta (TGF-beta).
Steven Stone, Barbara J Wold, Alexander Kamb   +2 more
exaly   +3 more sources

Cyclin-dependent kinase inhibitor p16INK4a and telomerase may co-modulate endothelial progenitor cells senescence

Ageing Research Reviews, 2008
Endothelial cells (ECs) damage is an initial and pivotal step in the formation of atherosclerosis. Endothelial progenitor cells (EPCs), which have been considered as the precursor of ECs, can migrate and home to the site of injured ECs to divide into mature ECs and keep the integrity of the endothelial monolayer.
Ling Liu, Xiao-Yan Zheng
exaly   +3 more sources

Familial uveal melanoma: absence of germline mutations involving the cyclin-dependent kinase-4 inhibitor gene (p16)

Ophthalmic Genetics, 1996
Arun D Singh, Carlo M Croce, Kishore K Wary   +2 more
exaly   +3 more sources

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

NeuroReport, 1996
Recent evidence indicates that an impairment of neuronal adaptive and reparative processes might be a key feature of the pathomechanism of Alzheimer's disease. Aberrations in the reparative neuronal response are likely to result from alterations of intracellular signal transduction cascades.
T, Arendt, L, Rödel, U, Gärtner, M, Holzer   +3 more
openaire   +2 more sources

Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

Molecular and Cellular Biochemistry, 1999
The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27.
D, Kaul, M, Kaur
openaire   +2 more sources

Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation.

Cancer research, 1995
The cyclin-dependent kinase inhibitors p16INK4/MTS1 and p15INK4B/MTS2 have been mapped to a region in chromosome 9 (921) that is deleted frequently in acute lymphoblastic leukemias and malignant gliomas. To gain insight into the functions of these inhibitors in lymphocytes and neuronal cells, we studied the expression of p15 and p16 during lymphocyte ...
A F, Lois, L T, Cooper, Y, Geng, T, Nobori, D, Carson   +4 more
openaire   +2 more sources

p16 Family Inhibitors of Cyclin-Dependent Kinases

1996
The origin and development of human tumors begins at the molecular level and involves a complex multi-step process. A feature common to many tumor cells is their ability to enter and progress through the cell division cycle under conditions where normal cells would either be quiescent or proliferating at a reduced rate.
Yan Li, Christopher W. Jenkins, Michael A. Nichols, Xiaoyu Wu, Kun-Liang Guan, Yue Xiong   +5 more
openaire   +1 more source

Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes

Leukemia Research, 1997
The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal blood disorders characterized by dyshematopoiesis with a frequent evolution to acute leukemia. Chromosomal deletions rather than translocations are the predominant karyotypic abnormalities in MDS, suggesting a recessive mechanism in the pathogenesis of MDS, such as inactivation of ...
T, Nakamaki, C, Bartram, T, Seriu, J, Kahan, K, Fukuchi, N, Tsuruoka, J W, Janssen, C W, Miller, H P, Koeffler   +8 more
openaire   +2 more sources

Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma

General Thoracic and Cardiovascular Surgery, 2014
The role of cell cycle inhibitors in tumorigenesis has been proven in various neoplasms; however, their roles in thymic tumors are still unclear. We examined the expression of cell cycle inhibitors such as those of the Cip/Kip family (p21, p27, and p57) and the INK-4/ARF family (p16 and p14) in thymoma and thymic carcinoma.Samples from 41 thymoma and ...
Mutsuko, Omatsu, Toshiaki, Kunimura, Tetsuya, Mikogami, Akira, Shiokawa, Atsuko, Masunaga, Tomoko, Nagai, Akihiko, Kitami, Takashi, Suzuki, Mitsutaka, Kadokura   +8 more
openaire   +2 more sources

Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin's T-Cell Lymphoma

Veterinary Pathology, 2007
The significance of p16/Rb tumor suppressor pathway inactivation in T-cell non-Hodgkin's lymphoma (NHL) remains incompletely understood. We used naturally occurring canine NHL to test the hypothesis that p16 inactivation has specific pathologic correlates. Forty-eight samples (22 T-cell NHL and 26 B-cell NHL) were included.
S P, Fosmire, R, Thomas, C M, Jubala, J W, Wojcieszyn, V E O, Valli, D M, Getzy, T L, Smith, L A, Gardner, M G, Ritt, J S, Bell, K P, Freeman, B E, Greenfield, S E, Lana, W C, Kisseberth, S C, Helfand, G R, Cutter, M, Breen, J F, Modiano   +17 more
openaire   +2 more sources