Results 151 to 160 of about 16,725 (189)

Role of the Cyclin-Dependent Kinase 4 and 6 Inhibitor Gene Family p15, p16, p18 and p19 in Leukemia and Lymphoma

Leukemia and Lymphoma, 1996
Neoplastic diseases are proliferative disorders characterized by uncoordinated cell growth. Cellular proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin dependent kinases (CDKs). Recently, CDK-inhibitors, which are a new class of small proteins involved in the negative regulation of the
B Opalka, R Siebert
exaly   +3 more sources

p16 Family Inhibitors of Cyclin-Dependent Kinases

1996
The origin and development of human tumors begins at the molecular level and involves a complex multi-step process. A feature common to many tumor cells is their ability to enter and progress through the cell division cycle under conditions where normal cells would either be quiescent or proliferating at a reduced rate.
Yan Li, Christopher W. Jenkins, Michael A. Nichols, Xiaoyu Wu, Kun-Liang Guan, Yue Xiong   +5 more
openaire   +1 more source

Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients [PDF]

British Journal of Cancer, 2015
Malignant pleural mesothelioma (MPM) is a rare and essentially incurable malignancy most often linked with occupational exposure to asbestos fibres. In common with other malignancies, the development and progression of MPM is associated with extensive dysregulation of cell cycle checkpoint proteins that modulate cell proliferation, apoptosis, DNA ...
Brian Harvey, Warren Thomas, Harvey B J   +2 more
exaly   +3 more sources

Structural integrity of the cyclin‐dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias

British Journal of Haematology, 1995
Summary The cyclin‐dependent kinase inhibitors known as p15, p16 and p18 have been suggested as candidates for tumour suppressor genes. We examined these genes for their alterations in 46 myeloid leukaemias and 15 myeloid leukaemia cell lines, p16 mRNA expression was studied in 41 myeloid leukaemias. The p15 and p16 genes were either deleted or mutated
Tsuyoshi Nakamaki, Norihiko Kawamata, Juurg Schwaller, Andreas Tobler, Martin Fey, Seppo Pakkala, Young Y. Lee, Byoung K. Kim, Kunihiko Fukuchi, Nobuyoshi Tsuruoka, Jerry Kahan, Carl W. Miller, H. Phillip Koeffler   +12 more
openaire   +2 more sources

Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation.

Cancer research, 1995
The cyclin-dependent kinase inhibitors p16INK4/MTS1 and p15INK4B/MTS2 have been mapped to a region in chromosome 9 (921) that is deleted frequently in acute lymphoblastic leukemias and malignant gliomas. To gain insight into the functions of these inhibitors in lymphocytes and neuronal cells, we studied the expression of p15 and p16 during lymphocyte ...
A F, Lois, L T, Cooper, Y, Geng, T, Nobori, D, Carson   +4 more
openaire   +2 more sources

Cyclin-dependent kinase inhibitors, p16 and p27, demonstrate different expression patterns in thymoma and thymic carcinoma

General Thoracic and Cardiovascular Surgery, 2014
The role of cell cycle inhibitors in tumorigenesis has been proven in various neoplasms; however, their roles in thymic tumors are still unclear. We examined the expression of cell cycle inhibitors such as those of the Cip/Kip family (p21, p27, and p57) and the INK-4/ARF family (p16 and p14) in thymoma and thymic carcinoma.Samples from 41 thymoma and ...
Mutsuko, Omatsu, Toshiaki, Kunimura, Tetsuya, Mikogami, Akira, Shiokawa, Atsuko, Masunaga, Tomoko, Nagai, Akihiko, Kitami, Takashi, Suzuki, Mitsutaka, Kadokura   +8 more
openaire   +2 more sources

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features [PDF]

Blood, 1995
A recently described putative tumor suppressor gene, the cyclin-dependent kinase 4 inhibitor (p16), has been shown to be altered by deletions and/or point mutations in various human cancers. To assess the incidence and clinico-biologic correlations of p16 homozygous deletion in hemopoietic tumors, we studied a panel of 244 DNA samples representative of
Giuseppe Cimino, Mandelli F, Alimena G   +2 more
exaly   +6 more sources

Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes

Leukemia Research, 1997
The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal blood disorders characterized by dyshematopoiesis with a frequent evolution to acute leukemia. Chromosomal deletions rather than translocations are the predominant karyotypic abnormalities in MDS, suggesting a recessive mechanism in the pathogenesis of MDS, such as inactivation of ...
T, Nakamaki, C, Bartram, T, Seriu, J, Kahan, K, Fukuchi, N, Tsuruoka, J W, Janssen, C W, Miller, H P, Koeffler   +8 more
openaire   +2 more sources

Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy

American Journal of Kidney Diseases, 2003
The goal of the current study was to examine the potential value of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor (CDKI) genes in the process of human kidney aging in vivo, and in the development of chronic allograft nephropathy (CAN).Expression of p16(INK4a) and p27(Kip1) CDKI genes was evaluated and compared in 20 normal human kidney ...
Antonia D'Errico, Pasquale Chieco, Elena Gabusi   +2 more
exaly   +3 more sources

Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin's T-Cell Lymphoma

Veterinary Pathology, 2007
The significance of p16/Rb tumor suppressor pathway inactivation in T-cell non-Hodgkin's lymphoma (NHL) remains incompletely understood. We used naturally occurring canine NHL to test the hypothesis that p16 inactivation has specific pathologic correlates. Forty-eight samples (22 T-cell NHL and 26 B-cell NHL) were included.
S P, Fosmire, R, Thomas, C M, Jubala, J W, Wojcieszyn, V E O, Valli, D M, Getzy, T L, Smith, L A, Gardner, M G, Ritt, J S, Bell, K P, Freeman, B E, Greenfield, S E, Lana, W C, Kisseberth, S C, Helfand, G R, Cutter, M, Breen, J F, Modiano   +17 more
openaire   +2 more sources