Results 71 to 80 of about 28,797 (249)

Oral Squamous Cell Carcinoma‐Risk Factors, Diagnosis, Treatment, and Prevention

Cancer Nexus, EarlyView.
ABSTRACT Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of oral mucosa and accounts for approximately 90% of oral cancers. In‐depth understanding of pathogenesis, hallmarks, and etiological factors is a crucial prerequisite for advancing the diagnosis and treatment for OSCC patients. This review aims to present the
Liping Wang, Xiaole Liu, Mengjie Chen, Ying Hu, Lilei Zhu   +4 more
wiley   +1 more source

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1 [PDF]

, 2014
The Epstein-Barr virus (EBV) nuclear antigen 3 family of protein is critical for the EBV-induced primary B-cell growth transformation process. Using a yeast two-hybrid screen we identified 22 novel cellular partners of the EBNA3s. Most importantly, among
Bazot, Q, Deschamps, T, Gruffat, H, Harth-Hertle, ML, Kempkes, B, Leblanc, P, Lotteau, V, Manet, E, Rabourdin-Combe, C, Siouda, M, Tafforeau, L, Tommasino, M   +11 more
core   +6 more sources

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, EarlyView.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

BMC Cancer, 2012
Background Promoter methylation of the tumor suppressor gene Cyclin A1 could be associated with Human Papillomavirus 16 (HPV16) induced Head and Neck Squamous Cell Carcinoma (HNSCC) and Cervical Carcinoma.
Weiss Daniel, Koopmann Mario, Basel Türker, Rudack Claudia   +3 more
doaj   +1 more source

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines. [PDF]

, 2018
Head and neck squamous cell carcinoma (HNSCC) is a common cancer diagnosis worldwide. Despite advances in treatment, HNSCC has very poor survival outcomes, emphasizing an ongoing need for development of improved therapeutic options.
Ailles, Laurie A, Barrett, John W, Black, Morgan, Boutros, Paul C, Datti, Alessandro, Fung, Kevin, Ghasemi, Farhad, MacNeil, Danielle, Mymryk, Joe S, Nichols, Anthony C, Palma, David A, Pinto, Nicole, Ruicci, Kara M, Sun, Ren X, Vizeacoumar, Frederick, Winquist, Eric, Yoo, John   +16 more
core   +1 more source

Current view of the inhibitor protein cyclin-dependent kinase р16, р27 and their role in the cell cycle

Кубанский научный медицинский вестник, 2016
Violations of the cell cycle have their own characteristics in the skin lesions. The greatest attention is paid to the research of cancers, whereas benign tumors of the skin insufficiently studied.
A. K. Aleksandrova, V. A. Smolynnikova
doaj  

Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is
Beril Erdem, Sibel Küçükyıldırım, Emel Sağlar, Zülfikar Polat, Hatice Mergen   +4 more
doaj   +1 more source

HPV-18 transformed cells fail to arrest in G1 in response to quercetin treatment [PDF]

, 2005
Previous work with primary human keratinocytes demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 with concomitant elevation of the cyclin-dependent kinase inhibitor (cdki ...
Alonso-Amelot, Beniston, Beniston, Bjeldanes, Cairney, Campo, Chang, Connolly, Cooper, Davies, de Villiers, Dell, Fazal, Galpin, Gillison, Hawley-Nelson, Hirayama, Ishidate, Jackson, Jones, M.S. Campo, Marliere, Nakayasu, O’Connor, Pecoraro, Pecoraro, Pennie, Plaumann, R.G. Beniston, Stanley, Suzuk, Suzuki, Syrjanen, Thierry, Togawa, Villalobos-Salazar, zur Hausen, zur Hausen   +37 more
core   +1 more source