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Anticancer Potential of Isoflavones: A Narrative Overview of Mechanistic Insights and Experimental Evidence from the Past Ten Years. [PDF]
BiomedicinesKnupp MS +4 more
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Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1997p27Kip1 is a member of the family of cyclin-dependent kinase inhibitors (CKIs), which play critical roles in the regulation of cell cycle. To study the transcriptional regulation that controls the expression of p27, we have isolated the p27 promoter, defined its transcription initiation site, and performed various analyses for sequences upstream to 3 ...
Zhang, Y., Lin, S. C.
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Expression of the cyclin-dependent kinase inhibitor p27 in keratoacanthoma
Journal of the American Academy of Dermatology, 2000Keratoacanthomas are characterized by initial rapid enlargement followed by clinical regression. A series of cyclin and cyclin-dependent kinase complexes regulate cell cycle progression. p27(kip) inhibits a variety of cyclin-cyclin-dependent kinase complexes in vitro and may act to hold eukaryotic cells in a quiescent state (G0).We examined expanding ...
W, Hu, T, Cook, C W, Oh, N S, Penneys
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Cycline‐Dependent Kinase Inhibitor, p27 (KIP1), Is Associated With Cholesteatoma
The Laryngoscope, 2001AbstractObjective Cyclin‐dependent kinases (CDKis) can arrest the cell cycle, which in turn inhibits the cell proliferation. P27 (KIP1) is a CDKi and acts as a tumor suppressor gene. In this study, we aimed to investigate the role of p27 CDKi in cholesteatoma, a disease characterized by the presence of hyperproliferative squamous epithelium.Study ...
Y A, Bayazít +3 more
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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.
The EMBO journal, 1997The p27(Kip1) protein associates with G1-specific cyclin-CDK complexes and inhibits their catalytic activity. p27(Kip1) is regulated at various levels, including translation, degradation by the ubiquitin/proteasome pathway and non-covalent sequestration. Here, we describe point mutants of p27 deficient in their interaction with either cyclins (p27(c-)),
J, Vlach, S, Hennecke, B, Amati
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Modulation of astrocyte proliferation by cyclin‐dependent kinase inhibitor p27Kip1
Glia, 2001AbstractWe previously demonstrated that type 1 astrocytes exhibited homotypic cell contact‐dependent inhibition of proliferation with increased expression of cyclin‐dependent kinase inhibitor p27Kip1. Here, we investigated the functional role of p27 in contact‐dependent inhibition of astrocytes and reactive gliosis in vitro and in vivo.
Ken, Koguchi +3 more
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Cyclin-dependant kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer
Journal of Cancer Research and Clinical Oncology, 2005Deregulation of the cell cycle is one of the important prerequisites for cancer development. p21 and p27 are both universal inhibitors of cyclin-dependent kinases and can therefore influence cell cycle or tumor progression. The aim of this study was to determine the influence of p21 and p27 expression on survival and chemotherapy response.165 patients ...
Annette, Schmider-Ross +5 more
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Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)
Molecular and Cellular Biochemistry, 1999The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27.
D, Kaul, M, Kaur
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