Results 121 to 130 of about 18,481 (166)
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Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy
American Journal of Physiology-Heart and Circulatory Physiology, 1997We postulated that the cyclin-dependent kinase inhibitors p21 and p27 could regulate the alterations in growth potential of cardiomyocytes during left ventricular hypertrophy (LVH). LVH was induced in adult rat hearts by aortic constriction (AC) and was monitored at days 0, 1, 3, 7, 14, 21, and 42 postoperation. Relative to sham-operated controls (SH),
J M, Li, G, Brooks
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The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27
Mutation Research/Reviews in Mutation Research, 2006Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome that affects approximately 1 in 6000 individuals. It is characterized by the development of tumors, named hamartomas, in the kidneys, heart, skin and brain. The latter often cause seizures, mental retardation, and a variety of developmental disorders, including autism.
Margit, Rosner +2 more
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Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines
Blood, 2000Abstract Chronic myeloid leukemia (CML) is a malignant stem cell disease characterized by an expansion of myeloid progenitor cells expressing the constitutively activated Bcr-Abl kinase. This oncogenic event causes a deregulation of apoptosis and cell cycle progression.
T, Jonuleit +6 more
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Cell Cycle-Dependent Phosphorylation of p27 Cyclin-Dependent Kinase (Cdk) Inhibitor by Cyclin E/Cdk2
Biochemical and Biophysical Research Communications, 1997The cyclin-dependent kinase (Cdk) inhibitor p27 interrupts progression of the cell cycle by inhibiting various cyclin/Cdk activities. Since the protein level of p27 does not correlate with its mRNA level or protein synthesis rate in most cases, it is suggested that degradation of the protein may be regulated via an unidentified mechanism(s) involving a
H, Morisaki +5 more
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Regulation of the cyclin dependent kinase inhibitor p27 in glioblastoma
2013Glioblastoma Multiforme (GBM) is the most common and most malignant brain tumour. The cyclin dependant kinase inhibitor p27 is commonly inactivated in this and many other cancers. p27 is an important negative regulator of the cell cycle which acts by inhibiting cyclinE/cdk2 and cyclinA/cdk2 complexes.
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Nature Medicine, 1997
The cell-cycle inhibitor p27 is a potential tumor suppressor, but its gene has never been found inactivated in human tumors. Because cell-cycle regulation of p27 cellular abundance occurs at the post-transcriptional level, we analyzed p27 protein expression and degradation in human colorectal carcinomas.
Loda M. +7 more
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The cell-cycle inhibitor p27 is a potential tumor suppressor, but its gene has never been found inactivated in human tumors. Because cell-cycle regulation of p27 cellular abundance occurs at the post-transcriptional level, we analyzed p27 protein expression and degradation in human colorectal carcinomas.
Loda M. +7 more
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The Role of Cyclin-dependent Kinase Inhibitor p27 in Squamous Cell Carcinoma of the Esophagus
Pathology - Research and Practice, 2001The level of p27 expression decreases during tumor development and progression. Loss of p27 protein provides independent prognostic information in breast, prostate, colon, stomach and lung carcinomas. We generated a new polyclonal antibody against p27 and carried out immunohistochemical analysis of p27 expression in 61 specimens of esophageal squamous ...
H, Shibata +3 more
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International Journal of Surgical Pathology, 2006
Pleomorphic xantoastrocytoma (PXA) is a rare, circumscribed astrocytic tumor that usually occurs in the superficial cerebral hemispheres in children and young adults. Most patients have a favorable prognosis, but recurrence and malignant transformation have been reported. In diffuse gliomas, approximately one third demonstrate mutations of the RB gene.
Maria D, Begnami +4 more
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Pleomorphic xantoastrocytoma (PXA) is a rare, circumscribed astrocytic tumor that usually occurs in the superficial cerebral hemispheres in children and young adults. Most patients have a favorable prognosis, but recurrence and malignant transformation have been reported. In diffuse gliomas, approximately one third demonstrate mutations of the RB gene.
Maria D, Begnami +4 more
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Future Oncology, 2010
The prognosis and clinical management of patients with cancer is commonly determined by traditional clinical and pathological factors. Nevertheless, patients may present with significantly different clinical outcomes despite similar clinicopathological features.
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The prognosis and clinical management of patients with cancer is commonly determined by traditional clinical and pathological factors. Nevertheless, patients may present with significantly different clinical outcomes despite similar clinicopathological features.
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Reduced Expression of Cyclin-dependent Kinase Inhibitor p27Kip1 in Feline Lymphoma
Veterinary Pathology, 2001Expression of p27Kip1 was identified in feline lymphoid tissues by immunohistochemistry. In normal lymphoid tissues, p27Kip1 was detected as a distinct nuclear stain in lymphocytes of the follicular mantle zone and interfollicular small lymphocytes, whereas activated lymphoblasts in the germinal center were negative. Lymphoid hyperplasia was similarly
B, Madewell +3 more
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