Results 11 to 20 of about 18,481 (166)
Cells, 2023 Erythrocyte biogenesis needs to be tightly regulated to secure oxygen transport and control plasma viscosity. The cytokine erythropoietin (Epo) governs erythropoiesis by promoting cell proliferation, differentiation, and survival of erythroid precursor ...
Fragka Pegka +4 more
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The AMPK/p27Kip1 Pathway as a Novel Target to Promote Autophagy and Resilience in Aged Cells
Cells, 2021 Once believed to solely function as a cyclin-dependent kinase inhibitor, p27Kip1 is now emerging as a critical mediator of autophagy, cytoskeletal dynamics, cell migration and apoptosis.
Lauren K. McKay, James P. White
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Control of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation [PDF]
Molecular and Cellular Biology, 2001 p27 is a key regulator of cell proliferation through inhibition of G(1) cyclin-dependent kinase (CDK) activity. Translation of the p27 mRNA is an important control mechanism for determining cellular levels of the inhibitor. Nearly all eukaryotic mRNAs are translated through a mechanism involving recognition of the 5' cap by eukaryotic initiation factor
W K, Miskimins +3 more
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Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation [PDF]
Leukemia, 1997 The cell cycle has been the object of extensive studies for the past years. A complex network of molecular interactions has been identified. In particular, a class of cell cycle inhibitory proteins has been cloned and characterized but details of the molecular mechanism of their action have yet to be resolved.
A, Alessandrini, D S, Chiaur, M, Pagano
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Scientific Reports, 2021 S-phase kinase associated protein 2 (Skp2), a member of the F-box family that constitute the largest known class of ubiquitin E3 specificity components, is responsible for recognizing and recruiting cyclin-dependent kinase inhibitor p27 for its ...
Kaizhao Hu +4 more
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Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27Kip1 [PDF]
Journal of Clinical Investigation, 1999 Proliferation and apoptosis are increased in many types of inflammatory diseases. A role for the cyclin kinase inhibitor p27(Kip1) (p27) in limiting proliferation has been shown. In this study, we show that p27(-/-) mesangial cells and fibroblasts have strikingly elevated rates of apoptosis, not proliferation, when deprived of growth factors. Apoptosis
K, Hiromura +4 more
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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Nature Communications, 2019 The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 (p27) folds upon binding to Cdk/cyclin complexes and during cell cycle progression p27 becomes phosphorylated, which triggers its ubiquitination and degradation.
Maksym Tsytlonok +14 more
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PLoS Biology, 2018 We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on
Niloofar Ale-Agha +20 more
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Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer. [PDF]
PLoS ONE, 2012 The levels of proteins that control the cell cycle are regulated by ubiquitin-mediated degradation via the ubiquitin-proteasome system (UPS) by substrate-specific E3 ubiquitin ligases. The cyclin-dependent kinase inhibitor, p27kip1 (p27), that blocks the
Kuang-Tzu Huang +5 more
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The SKP2‐p27 axis defines susceptibility to cell death upon CHK1 inhibition
Molecular Oncology, 2022 Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under‐replicated DNA or exogenous DNA damage.
Michael Lohmüller +7 more
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