Results 31 to 40 of about 18,481 (166)
UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27
Neurobiology of Disease, 2009 The UBE3A/E6-AP is known to function both as an E3 ubiquitin ligase of the ubiquitin proteasome system and as a transcriptional coactivator. E6-AP shows brain-specific imprinting and loss of function of maternally inherited E6-AP causes Angelman syndrome.
Amit Mishra +2 more
doaj +1 more source
MAST1 modulates neuronal differentiation and cell cycle exit via P27 in neuroblastoma cells
FEBS Open Bio, 2020 Although 19p13.13 microdeletion syndrome has been consistently associated with intellectual disability, overgrowth, and macrocephaly, the underlying mechanisms remain unclear.
Tianrui Jing +5 more
doaj +1 more source
Accumulation of the cyclin-dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation [PDF]
The EMBO Journal, 1997 Many types of vertebrate precursor cells divide a limited number of times before they stop and terminally differentiate. In no case is it known what causes them to stop dividing. We have been studying this problem in the proliferating precursor cells that give rise to postmitotic oligodendrocytes, the cells that make myelin in the central nervous ...
Durand, Beatrice, Gao, F, Raff, M
openaire +3 more sources
Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation. [PDF]
PLoS ONE, 2012 The PI3 kinase/AKT pathway has been shown to increase degradation of the p27 cyclin dependent kinase inhibitor through phosphorylation of consensus AKT sites on p27 and SKP2, and AKT driven proliferation may be checked by feedback mechanisms that ...
Hongyun Wang +5 more
doaj +1 more source
Mediating the death of dormant tumor cells
Molecular & Cellular Oncology, 2018 How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3 ...
Yuying Liu, Jiadi Lv, Bo Huang
doaj +1 more source
All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation
Cellular Physiology and Biochemistry, 2014 Background/Aims: All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells.
Eugene Lin +7 more
doaj +1 more source
Molecules, 2020 As a plant medicine, Oxalidaceae has been used to treat various diseases in Korea. However, there is little data on the anti-cancer efficacy of Oxalidaceae, particularly O. obtriangulata.
Eun-Jin An +5 more
doaj +1 more source
Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest [PDF]
Scientific Reports, 2016 AbstractPotent anti-cancer compounds FR901464 and its methyl-ketal derivative spliceostatin A (SSA) inhibit cell cycle progression at G1 and G2/M phases. These compounds bind to the spliceosome and inhibit the splicing reaction. However, the molecular mechanism underlying G1 arrest after SSA treatment remains unknown.
Takayuki Satoh, Daisuke Kaida
openaire +2 more sources
Taiwanese Journal of Obstetrics & Gynecology, 2016 Objective: Carfilzomib is a second-generation tetrapeptide epoxyketone proteasome inhibitor used in current clinical therapy of hematologic malignancies. The mechanism of proteasome inhibition in endometrial cancer is not very clear.
Yuanyuan Zhou +4 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Dysfunction of granulosa cells (GCs) leading to follicle atresia has been extensively studied as a major cause of premature ovarian insufficiency (POI), but the regulatory role of long non-coding RNAs (lncRNAs) in this process is still poorly understood.
Duan Li +8 more
doaj +1 more source