Results 41 to 50 of about 18,481 (166)
Antioxidants, 2020 Methionine sulfoxide (MetO) is an oxidative posttranslational modification that primarily occurs under oxidative stress conditions, leading to alteration of protein structure and function.
Beichen Jiang +5 more
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Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/p27-associated pathway. [PDF]
PLoS ONE, 2013 We previously showed that tanshinone IIA ameliorated the hypoxia-induced pulmonary hypertension (HPH) partially by attenuating pulmonary artery remodeling.
Ying Luo +7 more
doaj +1 more source
The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer.
Breast cancer research : BCR, 2001 p27 is an inhibitor of cyclin dependent kinase involved in the regulation of the cell cycle. In this commentary we discuss the current knowledge on p27 in breast cancer and its significance in predicting the outcome. p27 protein levels are high in most cases of breast carcinomas, are correlated with the levels of cyclin D1 and estrogen receptor, and ...
CHIARLE, Roberto +2 more
openaire +3 more sources
Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors [PDF]
Journal of Endocrinology, 1998 By regulating cyclin-cyclin-dependent kinase (CDK) complex activity, individual CDK inhibitors (CDKIs) are potential tumor suppressors. One of the CDKIs, p27/Kip1, binds to a variety of CDK-cyclin complexes. A link between loss of p27/Kip1 function and development of pituitary tumors was suggested by the formation of pituitary tumors in almost all mice
S, Takeuchi +5 more
openaire +2 more sources
Wound Healing Potential of Spirulina Protein on CCD-986sk Cells
Marine Drugs, 2019 Wound healing is a dynamic and complex process. The proliferation and migration of dermal fibroblasts are crucial for wound healing. Recent studies have indicated that the extracts from Spirulina platensis have a positive potential for wound healing ...
Ping Liu +4 more
doaj +1 more source
The transcription factor Cux1 regulates dendritic morphology of cortical pyramidal neurons. [PDF]
PLoS ONE, 2010 In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons.
Ning Li +3 more
doaj +1 more source
BMC Biology, 2010 Background The cyclin-dependent kinase (CDK) inhibitor p27Kip1 is downregulated in a majority of human cancers due to ectopic proteolysis by the ubiquitin-proteasome pathway.
Lu Lifang +4 more
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African Journal of Urology, 2022 Background Bladder cancer (BC) is the tenth most common cancer worldwide with urothelial carcinoma (UC) being the main histologic subtype. Survivin is an apoptosis inhibitor that is associated with tumor proliferation and invasion.
Noha Said Helal +2 more
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Neoplasia: An International Journal for Oncology Research, 2007 Pancreatic endocrine tumors (PETs) arise sporadically or are associated with multiple endocrine neoplasia type 1 (MENi) syndrome or von Hippel-Lindau syndrome. About 90% of patients with familial MENi display detectable MEN1 gene (menin) mutations.
Daniel Lindberg +2 more
doaj +1 more source
Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells. [PDF]
PLoS ONE, 2011 We previously reported that the USP19 deubiquitinating enzyme positively regulates proliferation in fibroblasts by stabilizing KPC1, a ubiquitin ligase for p27(Kip1).
Yu Lu +3 more
doaj +1 more source