Results 51 to 60 of about 18,481 (166)
Proliferative reactive gliosis is compatible with glial metabolic support and neuronal function
BMC Neuroscience, 2011 Background The response of mammalian glial cells to chronic degeneration and trauma is hypothesized to be incompatible with support of neuronal function in the central nervous system (CNS) and retina.
Fero Matthew +8 more
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The Cyclin-dependent Kinase Inhibitor p27Kip1 Is Involved in Thyroid Hormone-mediated Neuronal Differentiation [PDF]
Journal of Biological Chemistry, 1999 The thyroid hormone (triiodothyronine, T3) is essential for normal brain maturation. To determine the mechanisms by which T3 controls neuronal proliferation and differentiation, we have analyzed the effect of this hormone on the expression and activity of cell cycle-regulating molecules in neuroblastoma N2a-beta cells that overexpress the beta1 isoform
Pérez-Juste, Germán, Aranda, Ana
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The Cyclin-dependent Kinase Inhibitors p57 and p27 Regulate Neuronal Migration in the Developing Mouse Neocortex [PDF]
Journal of Biological Chemistry, 2007 Neuronal precursors remain in the proliferative zone of the developing mammalian neocortex until after they have undergone neuronal differentiation and cell cycle arrest. The newborn neurons then migrate away from the proliferative zone and enter the cortical plate. The molecules that coordinate migration with neuronal differentiation have been unclear.
Yasuhiro, Itoh +4 more
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Activity of the heat shock protein 90 inhibitor ganetespib in melanoma. [PDF]
PLoS ONE, 2013 Heat shock protein 90 (HSP90) is involved in the regulation of diverse biological processes such as cell signaling, proliferation and survival, and has been recently recognized as a potential target for cancer therapy.
Xinqi Wu +2 more
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Transmission distortion by loss of p21 or p27 cyclin-dependent kinase inhibitors following competitive spermatogonial transplantation [PDF]
Proceedings of the National Academy of Sciences, 2010 Spermatogonial stem cells (SSCs) undergo self-renewal division to support spermatogenesis. Although several positive regulators of SSC self-renewal have been identified, little is known about the mechanisms that negatively regulate SSCs. Here we developed a novel transplantation assay for SSCs and demonstrate that p21 and p27 cyclin-dependent kinase ...
Mito, Kanatsu-Shinohara +2 more
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Кубанский научный медицинский вестник, 2016 Violations of the cell cycle have their own characteristics in the skin lesions. The greatest attention is paid to the research of cancers, whereas benign tumors of the skin insufficiently studied.
A. K. Aleksandrova, V. A. Smolynnikova
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Endocrine Connections, 2018 Molecular targeted therapy of advanced neuroendocrine tumours (NETs) of the gastroenteropancreatic (GEP) system currently encompasses approved therapy with the mammalian target of rapamycin (mTOR) inhibitor everolimus and the multi-tyrosinkinase ...
E T Aristizabal Prada +1 more
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Journal of Pharmacological Sciences, 2006 .: During CNS development, multipotent neural stem cells give rise first to various kinds of specified precursor cells, which proliferate extensively before terminally differentiating into either neurons or glial cells.
Ishizaki Yasuki
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Chinese Journal of Lung Cancer, 2008 Background and objective S-phase kinase-associated protein 2 (Skp2) is one of the positive regulators of the cell cycle that promote Ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27.
Xiaohua HU +3 more
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Deregulation of the cyclin-dependent kinase inhibitor p27 as a putative candidate for transformation in Chlamydia trachomatis infected mesenchymal stem cells. [PDF]
AIMS Microbiol, 2023 Abu-Lubad MA, Al-Zereini W, Al-Zeer MA.
europepmc +1 more source