Cyclin-dependent kinases regulate the adult nervous system via the one-carbon-metabolism. [PDF]
Cell Death Dis, 2023 Angelin A.
europepmc +1 more source
Role of the cyclin-dependent kinase inhibitors in the development of cancer [PDF]
, 1995 Toshiyasu Hirama, HP Koeffler
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A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source
Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia. [PDF]
Microbiol Spectr, 2023 Kim J, Park EA, Shin MY, Park SJ.
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S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state [PDF]
, 1995 Christian Dahmann +2 more
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Advanced Science, EarlyView.Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra +9 more
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The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer. [PDF]
Int J Mol Sci, 2023 Javed A +3 more
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EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer
Advanced Science, EarlyView.Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang +7 more
wiley +1 more source
Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases. [PDF]
Cancers (Basel), 2023 Rusina P +11 more
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Role of PPARγ in Regulating a Cascade Expression of Cyclin-dependent Kinase Inhibitors, p18(INK4c) and p21(Waf1/Cip1), during Adipogenesis [PDF]
, 1999 Ron F. Morrison, Stephen R. Farmer
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