Results 11 to 20 of about 76,308 (284)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +2 more sources
Біологічні студії, 2014 This paper describes by mathematical modeling changes in the genetic control of cell in a state of proliferation and differentiation. It was constructed seventeen response surfaces for each of the speed rate constants that characterize the ...
I. V. Stadnyk, D. I. Sanagursky
doaj +1 more source
PP2A function toward mitotic kinases and substrates during [PDF]
BMB Reports, 2013 To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
doaj +1 more source
Cyclin-dependent kinases [PDF]
Genome Biology, 2014 SummaryCyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
openaire +2 more sources
Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough +30 more
core +3 more sources
Axonal Transport: CDKs as Traffic Signals for Motor-ists along the Axon? [PDF]
, 2010 SummaryA screen for axonal cargo mislocalization in Caenorhabditis elegans neurons implicates the cyclin-dependent kinases CDK-5 and PCT-1 and the cyclin CCY-1 in the regulation of the microtubule motor cytoplasmic ...
Holzbaur, Erika
core +1 more source
An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2
Chemistry Proceedings, 2021 CDKs are pivotal mediators essential for the cellular cycle progression. CDKs have relatively constant levels, and their activity is regulated by cyclins, proteins whose concentrations fluctuate during each cell cycle.
Abu Saim Mohammad Saikat
doaj +1 more source
Early Development of Mouse Embryos Null Mutant for the Cyclin A2 Gene Occurs in the Absence of Maternally Derived Cyclin A2 Gene Products [PDF]
, 2000 Progression through the mammalian cell cycle is regulated by the sequential activation and inactivation of the cyclin-dependent kinases. In adult cells, cyclin A2-dependent kinases are required for entry into S and M phases, completion of S phase, and ...
Winston, Nicola +7 more
core +3 more sources
Біологічні студії, 2015 Paper presents kinetic models of changes in genetic controlling systems of cells in the states of cell proliferation and differentiation. It was shown that the changes in the genetic control of cells in the state of proliferation and differentiation ...
I. V. Stadnyk, D. I. Sanagursky
doaj +1 more source
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source