Results 11 to 20 of about 382,305 (392)

Inhibition of cyclin-dependent kinases by p21. [PDF]

Molecular Biology of the Cell, 1995
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We have explored the interaction of p21 with the currently known Cdks. p21 effectively inhibits Cdk2, Cdk3, Cdk4, and Cdk6 kinases (
J. Harper, S. Elledge, K. Keyomarsi, B. Dynlacht, L. Tsai, Pumin Zhang, S. Dobrowolski, C. Bai, Lisa Connell‐Crowley, E. Swindell   +9 more
semanticscholar   +4 more sources

Cyclin-dependent kinases as mediators of aberrant transcription in prostate cancer [PDF]

Translational Oncology
Transcriptional control of gene expression is fundamental to all cellular processes. Conversely, transcriptional dysregulation is a hallmark of cancer.
Razia Rahman, Luke A. Selth
doaj   +2 more sources

Cyclin dependent kinases and their role in regulation of plant cell cycle

Biologia Plantarum, 2011
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains.
J. G. Tank, V. S. Thaker
doaj   +2 more sources

The history and future of targeting cyclin-dependent kinases in cancer therapy

Nature Reviews Drug Discovery, 2015
Erik S Knudsen
exaly   +2 more sources

CDK-dependent nuclear localization of B-Cyclin Clb1 promotes FEAR activation during meiosis I in budding yeast [PDF]

, 2013
Cyclin-dependent kinases (CDK) are master regulators of the cell cycle in eukaryotes. CDK activity is regulated by the presence, post-translational modification and spatial localization of its regulatory subunit cyclin.
A Sourirajan, AC Porter, AL Marston, Bela Novak, BH Lee, BN Tomson, CM Yellman, D D'amours, DA Mohl, E Queralt, E Queralt, F Bizzari, F Hu, F Liang, F Stegmeier, F Stegmeier, GW Kerr, GW Kerr, Katherine Louise Tibbles, KE Sawarynski, KR Benjamin, M Moore, M Petronczki, M Sullivan, ME Shin, N Grandin, Prakash Arumugam, R Azzam, R Visintin, R Visintin, RJ Kamieniecki, S Jensen, SL Jaspersen, Sourav Sarkar, TM Carlile, W Shou, W Shou, Y Zhai, Yanchang Wang   +38 more
core   +21 more sources

The Renaissance of Cyclin Dependent Kinase Inhibitors [PDF]

Cancers, 2022
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected
Ettl, Tobias, Schulz, Daniela, Bauer, Richard J.   +2 more
openaire   +3 more sources

Multiple cutaneous melanomas associated with gastric and brain metastases [PDF]

Anais Brasileiros de Dermatologia, 2016
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases.
Lara Caroline Grander, Fernanda Cabral, Alice Paixão Lisboa, Gabrielle Vale, Carlos Baptista Barcaui, Juan Manuel Pineiro Maceira   +5 more
doaj   +1 more source

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathway

Frontiers in Microbiology, 2022
The larval stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.
Chonglv Feng, Chonglv Feng, Zhe Cheng, Zhe Cheng, Zhijian Xu, Zhijian Xu, Ye Tian, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Damin Luo, Yanhai Wang, Yanhai Wang   +13 more
doaj   +1 more source

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1

Molecular & Cellular Oncology, 2021
Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids.
Pierre Raia, Jun Yu, Andreas Boland
doaj   +1 more source

In Silico and Cellular Differences Related to the Cell Division Process between the A and B Races of the Colonial Microalga Botryococcus braunii

Biomolecules, 2021
Botryococcus braunii produce liquid hydrocarbons able to be processed into combustion engine fuels. Depending on the growing conditions, the cell doubling time can be up to 6 days or more, which is a slow growth rate in comparison with other microalgae ...
Xochitl Morales-de la Cruz, Alejandra Mandujano-Chávez, Daniel R. Browne, Timothy P. Devarenne, Lino Sánchez-Segura, Mercedes G. López, Edmundo Lozoya-Gloria   +6 more
doaj   +1 more source