Results 21 to 30 of about 152,628 (302)

Survival-Promoting Activity of Inhibitors of Cyclin-Dependent Kinases on Primary Neurons Correlates with Inhibition of c-Jun Kinase-1

Neurobiology of Disease, 1997
Cyclin-dependent kinases and mitogen-activated protein kinases have been implicated in the regulation of cellular survival and apoptosis. We tested the effect of two mitogen-activated/cyclin-dependent kinase inhibitors, olomoucine and butyrolactone I, on
Marc A. Markus, Philipp J. Kahle, Andrea Winkler, Sonja Horstmann, Johanna M.H. Anneser, Gian Domenico Borasio   +5 more
doaj   +1 more source

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]

, 2016
BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N., Hammann, P., Harashima, H., Kramer, K., Nakagami, H., Nomura, Y., Schnittger, A.   +6 more
core   +2 more sources

Assessment of transcript and protein levels contributing to cell cycle control and gap junction connections in morphologically variable groups of porcine cumulus-oocyte complexes

Veterinární Medicína, 2010
Oocytes and somatic cumulus cells are connected by an extensive network of gap junctions. These connections contribute in a major way to oocyte maturation and developmental competence. Cumulus-oocyte complexes (COCs) were cultured in standard porcine IVM
P. Antosik, B. Kempisty, M. Jackowska, H. Piotrowska, D. Bukowska, M. Wozna, M. Lianeri, K.-P. Brussow, J.M. Jaskowski   +8 more
doaj   +1 more source

Cancer is a side effect of evolution of viruses and bacteria [PDF]

, 2011
Any human organism is home to viruses and bacteria. However, viruses (as well as other intracellular parasites) are interested in continuous division of the host cells.
Valentin Mitin
core   +2 more sources

Physicochemical Properties of analogs α-Aminophosphonates Drugs Determined via Molecular Dynamics Simulation

Asian Pacific Journal of Cancer Biology, 2019
Objective: Cyclin-dependent kinases (CDKs, play important roles in cell cycle regulation. Since deregulation of cyclins and/or alteration or absence of inhibitors has been associated with many cancers, there is strong interest in CDKs inhibitors that ...
Reihaneh Sabbaghzadeh
doaj   +1 more source

Cyclin-dependent kinases in C. elegans

Cell Division, 2006
Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth.
Boxem Mike
doaj   +1 more source

The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice

Scientific Reports, 2021
Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight.
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer   +6 more
doaj   +1 more source

Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

Acta Pharmaceutica Sinica B, 2021
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical ...
Kailin Li, Jieqiong You, Qian Wu, Wen Meng, Qiaojun He, Bo Yang, Chengliang Zhu, Ji Cao   +7 more
doaj   +1 more source

T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue [PDF]

, 2007
As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast.
Dissmeyer, N., , Nowack, M., Pusch, S., Stals, H., Inzé, D., Grini, P., Schnittger, A.   +7 more
core   +2 more sources