Results 41 to 50 of about 114,714 (200)
Медицинский совет, 2018 Treatment of choice of metastatic hormone-dependent breast cancer regardless of age is hormone therapy (HT) even with visceral metastases. Now we have a new class of drugs called inhibitors of cyclin-dependent kinases 4/6, which significantly increase ...
S. F. Menshikova +3 more
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Plant CDKs—Driving the Cell Cycle through Climate Change
Plants, 2021 In a growing population, producing enough food has become a challenge in the face of the dramatic increase in climate change. Plants, during their evolution as sessile organisms, developed countless mechanisms to better adapt to the environment and its ...
Aline Köhn Carneiro +4 more
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Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Infectious Agents and Cancer, 2020 The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor ...
Shaian Tavakolian +2 more
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Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes [PDF]
, 2003 Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities.
Datwyler, D. A. +11 more
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Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27
Open Biology, 2021 The use of CDK4/6 inhibitors in the treatment of a wide range of cancers is an area of ongoing investigation. Despite their increasing clinical use, there is limited understanding of the determinants of sensitivity and resistance to these drugs.
Betheney R. Pennycook, Alexis R. Barr
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Cyclin-Dependent Kinases: CAK-handed kinase activation [PDF]
, 1995 A protein kinase that activates cyclin-dependent kinases has been identified as a related catalytic subunit in association with a novel cyclin regulatory subunit – it is itself a cyclin-dependent ...
Clarke, PR, Clarke, Paul R.
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Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers
Frontiers in Oncology, 2018 Ovarian, uterine/endometrial, and cervical cancers are major gynecologic malignancies estimated to cause nearly 30,000 deaths in 2018 in US. Defective cell cycle regulation is the hallmark of cancers underpinning the development and progression of the ...
Z. Ping Lin +2 more
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CDK12: A Potent Target and Biomarker for Human Cancer Therapy
Cells, 2020 Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription.
Shujing Liang +6 more
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Frontiers in Pharmacology, 2021 Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood.
Olivier Preynat-Seauve +11 more
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Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]
, 2010 Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E +3 more
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