Results 31 to 40 of about 2,935,830 (275)

The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice

Scientific Reports, 2021
Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight.
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer   +6 more
doaj   +1 more source

Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

Acta Pharmaceutica Sinica B, 2021
Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical ...
Kailin Li, Jieqiong You, Qian Wu, Wen Meng, Qiaojun He, Bo Yang, Chengliang Zhu, Ji Cao   +7 more
doaj   +1 more source

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

Cell Division, 2012
The retinoblastoma (RB) family of proteins are found in organisms as distantly related as humans, plants, and insects. These proteins play a key role in regulating advancement of the cell division cycle from the G1 to S-phases.
Henley Shauna A, Dick Frederick A
doaj   +1 more source

The Renaissance of Cyclin Dependent Kinase Inhibitors [PDF]

Cancers, 2022
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected
Ettl, Tobias, Schulz, Daniela, Bauer, Richard J.   +2 more
openaire   +2 more sources

Plant CDKs—Driving the Cell Cycle through Climate Change

Plants, 2021
In a growing population, producing enough food has become a challenge in the face of the dramatic increase in climate change. Plants, during their evolution as sessile organisms, developed countless mechanisms to better adapt to the environment and its ...
Aline Köhn Carneiro, Patrícia da Fonseca Montessoro, Adriana Flores Fusaro, Bruna Gino Araújo, Adriana Silva Hemerly   +4 more
doaj   +1 more source

Ribociclib in the first-line therapy for metastatic hormone-dependent HER2-negative breast cancer in patients with intact ovarian function

Медицинский совет, 2018
Treatment of choice of metastatic hormone-dependent breast cancer regardless of age is hormone therapy (HT) even with visceral metastases. Now we have a new class of drugs called inhibitors of cyclin-dependent kinases 4/6, which significantly increase ...
S. F. Menshikova, M. A. Frolova, E. V. Glazkova, M. B. Stenina   +3 more
doaj   +1 more source

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
core   +1 more source

Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers

Infectious Agents and Cancer, 2020
The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor ...
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo   +2 more
doaj   +1 more source

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a [PDF]

, 2012
The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry.
Engels, Kristin K., Marhofer, Richard J., Bender, Frank, Mottram, Jeremy C., Gassel, Michael, Selzer, Paul M., Fernandez, Maria L. Suarez   +6 more
core   +1 more source

Identifying a role for Ciz1 in the DNA damage response [PDF]

, 2011
In proliferating cells, cell cycle arrest and DNA repair are induced upon detection of DNA damage. The DNA damage response (DDR) to double strand DNA breaks is mediated by phosphatidylinositol 3-kinase-like protein kinases (PIKKs), which propagate DDR ...
Roper, Katherine
core   +6 more sources