Results 11 to 20 of about 2,935,830 (275)

Cyclin dependent kinases and their role in regulation of plant cell cycle

Biologia Plantarum, 2011
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains.
J. G. Tank, V. S. Thaker
doaj   +2 more sources

Inhibition of cyclin-dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation. [PDF]

Mol Oncol
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Watlington WK, Dayanidhi DL, Zokaasadi M, Mantyh JB, Olawuni PD, Rupprecht G, Force JM, McCall S, Bahl AK, Hsu DS, Somarelli JA.   +10 more
europepmc   +2 more sources

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E, Ainscough, Justin F X, Coverley, Dawn, Copeland, Nikki A   +3 more
core   +4 more sources

The Role of Pharmacokinetics and Pharmacodynamics in Early Drug Development with reference to the Cyclin-dependent Kinase (Cdk) Inhibitor - Roscovitine. [PDF]

, 2011
Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. This is an essential issue in cancer treatment due to its high toxicity. During the last decade, cyclin-dependent kinase
Hassan, Moustapha, Sallam, Hatem, Hassan, Zuzana   +2 more
core   +4 more sources

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathway

Frontiers in Microbiology, 2022
The larval stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans.
Chonglv Feng, Chonglv Feng, Zhe Cheng, Zhe Cheng, Zhijian Xu, Zhijian Xu, Ye Tian, Ye Tian, Huimin Tian, Fan Liu, Damin Luo, Damin Luo, Yanhai Wang, Yanhai Wang   +13 more
doaj   +1 more source

Cyclin-dependent kinases and rare developmental disorders

Orphanet Journal of Rare Diseases, 2020
Extensive studies in the past 30 years have established that cyclin-dependent kinases (CDKs) exert many diverse, important functions in a number of molecular and cellular processes that are at play during development.
Pierre Colas
doaj   +1 more source

In Silico and Cellular Differences Related to the Cell Division Process between the A and B Races of the Colonial Microalga Botryococcus braunii

Biomolecules, 2021
Botryococcus braunii produce liquid hydrocarbons able to be processed into combustion engine fuels. Depending on the growing conditions, the cell doubling time can be up to 6 days or more, which is a slow growth rate in comparison with other microalgae ...
Xochitl Morales-de la Cruz, Alejandra Mandujano-Chávez, Daniel R. Browne, Timothy P. Devarenne, Lino Sánchez-Segura, Mercedes G. López, Edmundo Lozoya-Gloria   +6 more
doaj   +1 more source

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core   +3 more sources

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1

Molecular & Cellular Oncology, 2021
Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids.
Pierre Raia, Jun Yu, Andreas Boland
doaj   +1 more source

CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions

Asian Pacific Journal of Cancer Biology, 2020
Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity.
Muzna Shah, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, Shamim Mushtaq   +5 more
doaj   +1 more source