Results 11 to 20 of about 114,714 (200)

Cyclin-dependent kinases in C. elegans

Cell Division, 2006
Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth.
Boxem Mike
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Cyclin dependent kinases and their role in regulation of plant cell cycle [PDF]

Biologia Plantarum, 2011
Plants have capability to optimize its architecture by using CDK pathways. It involves diverse types of cyclin dependent kinase enzymes (CDKs). CDKs are classified in to eight classes (CDKA to CDKG and CKL) based on the recognized cyclin-binding domains.
J. G. Tank, V. S. Thaker
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Targets of cyclin-dependent protein kinases [PDF]

Current Opinion in Cell Biology, 1993
Our current understanding of the eukaryotic cell cycle attributes a key regulatory role to cyclin-dependent protein kinases. It is important, therefore, to identify the physiological substrates of these kinases, and to understand how the phosphorylation of such proteins promotes cell cycle progression.
Nigg, E. A.
openaire   +3 more sources

In Silico and Cellular Differences Related to the Cell Division Process between the A and B Races of the Colonial Microalga Botryococcus braunii

Biomolecules, 2021
Botryococcus braunii produce liquid hydrocarbons able to be processed into combustion engine fuels. Depending on the growing conditions, the cell doubling time can be up to 6 days or more, which is a slow growth rate in comparison with other microalgae ...
Xochitl Morales-de la Cruz, Alejandra Mandujano-Chávez, Daniel R. Browne, Timothy P. Devarenne, Lino Sánchez-Segura, Mercedes G. López, Edmundo Lozoya-Gloria   +6 more
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Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1

Molecular & Cellular Oncology, 2021
Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids.
Pierre Raia, Jun Yu, Andreas Boland
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The Renaissance of Cyclin Dependent Kinase Inhibitors [PDF]

Cancers, 2022
Cyclin-dependent kinases (CDK) regulate cell cycle progression. During tumor development, altered expression and availability of CDKs strongly contribute to impaired cell proliferation, a hallmark of cancer. In recent years, targeted inhibition of CDKs has shown considerable therapeutic benefit in a variety of tumor entities. Their success is reflected
Ettl, Tobias, Schulz, Daniela, Bauer, Richard J.   +2 more
openaire   +3 more sources

CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions

Asian Pacific Journal of Cancer Biology, 2020
Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity.
Muzna Shah, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, Shamim Mushtaq   +5 more
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Identification of critical parameters of cell transition from the state of proliferation to the state of differentiation

Біологічні студії, 2014
This paper describes by mathematical modeling changes in the genetic control of cell in a state of proliferation and differentiation. It was constructed seventeen response surfaces for each of the speed rate constants that characterize the ...
I. V. Stadnyk, D. I. Sanagursky
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PP2A function toward mitotic kinases and substrates during [PDF]

BMB Reports, 2013
To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
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High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
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