Results 21 to 30 of about 382,305 (392)

The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

International Journal of Molecular Sciences, 2020
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are regulated by interactions with cyclins and CDK inhibitors (CKIs).
L. Ding, Jiaqi Cao, Wen-Lien Lin, Hongjian Chen, Xianhui Xiong, Hongshun Ao, Min Yu, Jie Lin, Qing-hua Cui   +8 more
semanticscholar   +1 more source

CDKs family -a glimpse into the past and present: from cell cycle control to current biological functions

Asian Pacific Journal of Cancer Biology, 2020
Cyclin-dependent kinases (CDKs) are the catalytic subunits or protein kinases characterized by separate subunit “cyclin” that are essential for their enzymatic activity.
Muzna Shah, Muhammad Fazal Hussain Qureshi, Danish Mohammad, Mahira Lakhani, Tabinda Urooj, Shamim Mushtaq   +5 more
doaj   +1 more source

Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy.

Cancer Discovery, 2020
Drugs targeting the cell cycle-regulatory cyclin-dependent kinase (CDK) 4 and 6 have been approved for the treatment of hormone receptor-positive breast cancer, and inhibitors targeting other cell-cycle CDKs are currently in clinical trials.
J. Chou, D. Quigley, Troy M Robinson, F. Feng, A. Ashworth   +4 more
semanticscholar   +1 more source

PP2A function toward mitotic kinases and substrates during [PDF]

BMB Reports, 2013
To maintain cellular homeostasis against the demands of theextracellular environment, a precise regulation of kinases andphosphatases is essential. In cell cycle regulation mechanisms,activation of the cyclin-dependent kinase (CDK1) and cyclin Bcomplex ...
Ae Lee Jeong, Young Yang
doaj   +1 more source

Association of Cyclin-Dependent Kinases 4 and 6 Inhibitors With Survival in Patients With Hormone Receptor–Positive Metastatic Breast Cancer

JAMA Network Open, 2020
Key Points Question Is the addition of cyclin-dependent kinases 4 and 6 inhibitors to endocrine therapy associated with increased overall survival vs endocrine therapy alone among patients with hormone receptor–positive, ERBB2-negative metastatic breast ...
Jinming Li, Xingfa Huo, Fuxing Zhao, Dengfeng Ren, Raees Ahmad, Xinyue Yuan, F. Du, Jiuda Zhao   +7 more
semanticscholar   +1 more source

Inhibitors of mammalian G1 cyclin-dependent kinases.

Genes & Development, 1995
Biologic machines need brakes, and the nature and fidelity of their operation cannot be unraveled without some prior understanding of how accelerators work. The discoveD] of mammalian G1 cyclins just 4 years ago and the identification of their associated
C. Sherr, James M. Roberts
semanticscholar   +1 more source

Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer [PDF]

, 2014
BACKGROUND: Lung cancer is one of the leading causes of cancer death worldwide. Even with complete resection, the prognosis of early-stage non-small cell lung cancer is poor due to local and distant recurrence, and it remains unclear which biomarkers are
Hideki Ishihara, Hiroshi Kubo, Kazuya Uchino, Masahiro Yoshimura, Sachiyo Tada, Satoshi Suzuki, Takashi Kondo, Takashi Suzuki, Tomoko Matsushima   +8 more
core   +1 more source

Identification of critical parameters of cell transition from the state of proliferation to the state of differentiation

Біологічні студії, 2014
This paper describes by mathematical modeling changes in the genetic control of cell in a state of proliferation and differentiation. It was constructed seventeen response surfaces for each of the speed rate constants that characterize the ...
I. V. Stadnyk, D. I. Sanagursky
doaj   +1 more source

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Ainscough, Berezney, Brown, Cardoso, Chevalier, Cook, Coverley, Coverley, den Hollander, Dijkwel, Djeliova, Fujita, Furstenthal, Geng, Geng, Harper, Hozak, Krude, Lowe, Mailand, Mitsui, Moore, Parisi, Radichev, Sherr, Stoeber, Su, Takeda, Tatsumi, Wilmes, Wohlschlegel   +30 more
core   +3 more sources

An In Silico Approach for Potential Natural Compounds as Inhibitors of Protein CDK1/Cks2

Chemistry Proceedings, 2021
CDKs are pivotal mediators essential for the cellular cycle progression. CDKs have relatively constant levels, and their activity is regulated by cyclins, proteins whose concentrations fluctuate during each cell cycle.
Abu Saim Mohammad Saikat
doaj   +1 more source