Results 21 to 30 of about 76,308 (284)

Survival-Promoting Activity of Inhibitors of Cyclin-Dependent Kinases on Primary Neurons Correlates with Inhibition of c-Jun Kinase-1

Neurobiology of Disease, 1997
Cyclin-dependent kinases and mitogen-activated protein kinases have been implicated in the regulation of cellular survival and apoptosis. We tested the effect of two mitogen-activated/cyclin-dependent kinase inhibitors, olomoucine and butyrolactone I, on
Marc A. Markus, Philipp J. Kahle, Andrea Winkler, Sonja Horstmann, Johanna M.H. Anneser, Gian Domenico Borasio   +5 more
doaj   +1 more source

Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer [PDF]

, 2014
BACKGROUND: Lung cancer is one of the leading causes of cancer death worldwide. Even with complete resection, the prognosis of early-stage non-small cell lung cancer is poor due to local and distant recurrence, and it remains unclear which biomarkers are
Hideki Ishihara, Hiroshi Kubo, Kazuya Uchino, Masahiro Yoshimura, Sachiyo Tada, Satoshi Suzuki, Takashi Kondo, Takashi Suzuki, Tomoko Matsushima   +8 more
core   +1 more source

Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for patients with hepatocellular carcinoma

BMC Gastroenterology, 2022
Background Hepatocellular carcinoma (HCC) was frequently considered as a kind of malignant tumor with a poor prognosis. Cyclin-dependent kinases (CDK) 4 was considered to be cell-cycle-related CDK gene.
Zhong-liu Wei, Xin Zhou, Chen-lu Lan, Hua-sheng Huang, Xi-wen Liao, Shu-tian Mo, Yong-guang Wei, Tao Peng   +7 more
doaj   +1 more source

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]

, 2016
BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N., Hammann, P., Harashima, H., Kramer, K., Nakagami, H., Nomura, Y., Schnittger, A.   +6 more
core   +2 more sources

Assessment of transcript and protein levels contributing to cell cycle control and gap junction connections in morphologically variable groups of porcine cumulus-oocyte complexes

Veterinární Medicína, 2010
Oocytes and somatic cumulus cells are connected by an extensive network of gap junctions. These connections contribute in a major way to oocyte maturation and developmental competence. Cumulus-oocyte complexes (COCs) were cultured in standard porcine IVM
P. Antosik, B. Kempisty, M. Jackowska, H. Piotrowska, D. Bukowska, M. Wozna, M. Lianeri, K.-P. Brussow, J.M. Jaskowski   +8 more
doaj   +1 more source

Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]

, 2015
Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris, De Veylder, Lieven, Huysman, Marie, Tanaka, Atsuko, Vyverman, Wim   +4 more
core   +2 more sources

Physicochemical Properties of analogs α-Aminophosphonates Drugs Determined via Molecular Dynamics Simulation

Asian Pacific Journal of Cancer Biology, 2019
Objective: Cyclin-dependent kinases (CDKs, play important roles in cell cycle regulation. Since deregulation of cyclins and/or alteration or absence of inhibitors has been associated with many cancers, there is strong interest in CDKs inhibitors that ...
Reihaneh Sabbaghzadeh
doaj   +1 more source

An evolutionary perspective on the kinome of malaria parasites [PDF]

, 2012
Malaria parasites belong to an ancient lineage that diverged very early from the main branch of eukaryotes. The approximately 90-member plasmodial kinome includes a majority of eukaryotic protein kinases that clearly cluster within the AGC, CMGC, TKL ...
Andrew B. Tobin, Carvalho T. G., Christian Doerig, Eric Talevich, Natarajan Kannan, Wells T. N., Wilson R. J.   +6 more
core   +1 more source

Cyclin-dependent kinases in C. elegans

Cell Division, 2006
Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth.
Boxem Mike
doaj   +1 more source

The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice

Scientific Reports, 2021
Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight.
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer   +6 more
doaj   +1 more source