Results 31 to 40 of about 382,305 (392)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]
, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C. +2 more
core +2 more sources
Біологічні студії, 2015 Paper presents kinetic models of changes in genetic controlling systems of cells in the states of cell proliferation and differentiation. It was shown that the changes in the genetic control of cells in the state of proliferation and differentiation ...
I. V. Stadnyk, D. I. Sanagursky
doaj +1 more source
Cyclin‐dependent kinase‐5 in neurodegeneration [PDF]
Journal of Neurochemistry, 2004 AbstractCyclin‐dependent kinase‐5 (CDK5) is predominantly active in the nervous system and it is well established that CDK5 is essential in neuronal development. In addition to its recognized role in development, there is increasing evidence that CDK5 may be involved in the pathogenesis of several neurodegenerative disorders.
Gail V.W. Johnson, Shirley B. Shelton
openaire +3 more sources
Axonal Transport: CDKs as Traffic Signals for Motor-ists along the Axon? [PDF]
, 2010 SummaryA screen for axonal cargo mislocalization in Caenorhabditis elegans neurons implicates the cyclin-dependent kinases CDK-5 and PCT-1 and the cyclin CCY-1 in the regulation of the microtubule motor cytoplasmic ...
Holzbaur, Erika
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Veterinární Medicína, 2010 Oocytes and somatic cumulus cells are connected by an extensive network of gap junctions. These connections contribute in a major way to oocyte maturation and developmental competence. Cumulus-oocyte complexes (COCs) were cultured in standard porcine IVM
P. Antosik +8 more
doaj +1 more source
Early Development of Mouse Embryos Null Mutant for the Cyclin A2 Gene Occurs in the Absence of Maternally Derived Cyclin A2 Gene Products [PDF]
, 2000 Progression through the mammalian cell cycle is regulated by the sequential activation and inactivation of the cyclin-dependent kinases. In adult cells, cyclin A2-dependent kinases are required for entry into S and M phases, completion of S phase, and ...
Winston, Nicola +7 more
core +3 more sources
The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]
, 2016 Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng +4 more
core +1 more source
Asian Pacific Journal of Cancer Biology, 2019 Objective: Cyclin-dependent kinases (CDKs, play important roles in cell cycle regulation. Since deregulation of cyclins and/or alteration or absence of inhibitors has been associated with many cancers, there is strong interest in CDKs inhibitors that ...
Reihaneh Sabbaghzadeh
doaj +1 more source
Scientific Reports, 2021 Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice. Treatment of obese individuals will require therapies that reverse the detrimental effects of excess body weight.
Nabil Rabhi +6 more
doaj +1 more source
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source