Results 41 to 50 of about 382,305 (392)

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Bertrand, Philippe, Bretteville, Alexis, Buée, Luc, Bégard, Séverine, Delacourte, André, Hamdane, Malika, Sambo, Anne-Véronique, Schindowski, Katharina   +7 more
core   +1 more source

Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6.

Angewandte Chemie, 2019
Cyclin-dependent kinases 4 and 6 (CDK4/6) are key regulators of the cell cycle, and there are FDA-approved CDK4/6 inhibitors for treating patients with metastatic breast cancer.
Baishan Jiang, Eric S. Wang, K. Donovan, Yanke Liang, E. Fischer, Tinghu Zhang, N. Gray   +6 more
semanticscholar   +1 more source

Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]

, 2015
Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris, De Veylder, Lieven, Huysman, Marie, Tanaka, Atsuko, Vyverman, Wim   +4 more
core   +2 more sources

Are all cyclin-dependent kinases 4/6 inhibitors created equal?

npj Breast Cancer, 2019
The harnessing in clinical practice of cyclin-dependent kinases 4/6 inhibitors, namely palbociclib, ribociclib, and abemaciclib, has substantially changed the therapeutic approach for hormone receptor-positive metastatic breast cancer (BC).
A. Marra, G. Curigliano
semanticscholar   +1 more source

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1 [PDF]

, 2016
BACKGROUND: Modulation of protein activity by phosphorylation through kinases and subsequent de-phosphorylation by phosphatases is one of the most prominent cellular control mechanisms.
Dissmeyer, N., Hammann, P., Harashima, H., Kramer, K., Nakagami, H., Nomura, Y., Schnittger, A.   +6 more
core   +2 more sources

Ribociclib in the first-line therapy for metastatic hormone-dependent HER2-negative breast cancer in patients with intact ovarian function

Медицинский совет, 2018
Treatment of choice of metastatic hormone-dependent breast cancer regardless of age is hormone therapy (HT) even with visceral metastases. Now we have a new class of drugs called inhibitors of cyclin-dependent kinases 4/6, which significantly increase ...
S. F. Menshikova, M. A. Frolova, E. V. Glazkova, M. B. Stenina   +3 more
doaj   +1 more source

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

Cell Division, 2012
The retinoblastoma (RB) family of proteins are found in organisms as distantly related as humans, plants, and insects. These proteins play a key role in regulating advancement of the cell division cycle from the G1 to S-phases.
Henley Shauna A, Dick Frederick A
doaj   +1 more source

Plant CDKs—Driving the Cell Cycle through Climate Change

Plants, 2021
In a growing population, producing enough food has become a challenge in the face of the dramatic increase in climate change. Plants, during their evolution as sessile organisms, developed countless mechanisms to better adapt to the environment and its ...
Aline Köhn Carneiro, Patrícia da Fonseca Montessoro, Adriana Flores Fusaro, Bruna Gino Araújo, Adriana Silva Hemerly   +4 more
doaj   +1 more source

Therapeutic targeting of transcriptional cyclin-dependent kinases

Transcription, 2018
The fact that many cancer types display transcriptional addiction driven by dysregulation of oncogenic enhancers and transcription factors has led to increased interest in a group of protein kinases, known as transcriptional cyclin dependent kinases ...
M. Galbraith, Heather Bender, J. Espinosa   +2 more
semanticscholar   +1 more source

Cyclin-dependent kinases: a family portrait [PDF]

Nature Cell Biology, 2009
To the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits. Based on sequence similarity, the human genome contains 21 genes encoding CDKs and five additional genes encoding a more distant group of ...
Tony Hunter, Debra J. Wolgemuth, Tim Hunt, Jill M. Lahti, David O. Morgan, Li-Huei Tsai, Marcos Malumbres, Gerard Manning, Ed Harlow   +8 more
openaire   +3 more sources