Results 111 to 120 of about 230,940 (319)
Complex Systems Analysis of Cell Cycling Models in Carcinogenesis [PDF]
arXiv, 2004 Carcinogenesis is a complex process that involves dynamically inter-connected modular sub-networks that evolve under the influence of micro-environmentally induced perturbations, in non-random, pseudo-Markov chain processes. An appropriate n-stage model of carcinogenesis involves therefore n-valued Logic treatments of nonlinear dynamic transformations ...
arxiv
Advanced Science, EarlyView.KLF5 is highly expressed in BLBC patients and promotes Cyclin D1 and XPO1 transcription, ultimately leading to the inactivation of RB1. Both XPO1 inhibitor (KPT‐330) and CDK4/6 inhibitor (Palbociclib) can enhance RB1 activity and exert antitumor effects. It has been proved that the combination of KPT‐330 and Palbociclib can inhibit the proliferation of
Yu Tang +12 more
wiley +1 more source
Consequence of the tumor‐associated conversion to cyclin D1b
EMBO Molecular Medicine, 2015 Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to
Michael A Augello +12 more
doaj +1 more source
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered Bladder Cancer
Advanced Science, EarlyView.Coatomer protein complex subunit α facilitates the transport of the cargo protein LRPPRC across the Golgi complex and enhances its stability, thereby increasing LRPPRC expression; LRPPRC promotes the stability of ID3 mRNA in an m6A‐dependent manner, thereby decreasing the transcriptional activity of p16 and p21, which leads to increased erdafitinib ...
Huayuan Zhao +10 more
wiley +1 more source
Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
Molecular Systems Biology, 2009 Cyclin‐dependent kinase (Cdk) both promotes mitotic entry (spindle assembly and anaphase) and inhibits mitotic exit (spindle disassembly and cytokinesis), leading to an elegant quantitative hypothesis that a single cyclin oscillation can function as a ...
Benjamin J Drapkin +4 more
doaj +1 more source
Anti-Cancer Effect of Liriodenine on Human Lung Cancer Cells
Kaohsiung Journal of Medical Sciences, 2004 Our previous work demonstrated that liriodenine, an isoquinoline alkaloid isolated from plant species of many genera, exhibits a potent cytotoxic effect on various types of human cancer cells.
Hui-Chiu Chang
doaj +1 more source
Coordinated synthesis of the nuclear protein cyclin and DNA in serum‐stimulated quiescent 3T3 cells [PDF]
, 1984 R Bravo
openalex +1 more source
Advanced Science, EarlyView.In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao +19 more
wiley +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 4806-4815, December 2022., 2022 Over 65% and over 90% volume reduction of brain metastases at 6 months post‐SRT predicts good local control. Beneficial volume reduction may require increasing the dose to GTV D80 in the LQ model: α/β = 20, and inhomogeneous dose distribution may be required for SRT for brain metastases.
Naoyuki Kanayama +7 more
wiley +1 more source
Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes. [PDF]
, 1987 Pekka Kurki +3 more
openalex +1 more source