Results 151 to 160 of about 230,940 (319)
Advanced Science, EarlyView.PDCD11 overexpression highly correlates to poor prognosis in p53‐mutant breast and colon cancers. Through interaction with C‐MYC in the nucleoplasm, PDCD11 hinders C‐MYC‐induced SKP2 from binding to the C‐MYC MB2 domain for ubiquitination, thereby stabilizing C‐MYC to drive tumor progression.
Li Ding +12 more
wiley +1 more source
Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila
Cell Reports, 2020 Summary: The Drosophila midgut is an excellent system for characterizing cell cycle regulation in the context of tissue homeostasis. Two major progenitor cell types populate the midgut: mitotic intestinal stem cells and their post-mitotic daughters ...
Reegan J. Willms +2 more
doaj
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. [PDF]
, 1994 Jun‐ya Kato +3 more
openalex +1 more source
AGING MEDICINE, EarlyView.ABSTRACT Purpose Premature cellular senescence is a pivotal process in aging and age‐related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with different compositions. Therefore, understanding the complex dynamics of senescence programs
Vinícius Pierdoná +6 more
wiley +1 more source
Cyclins, Cdks, and Cyclin Kinase Inhibitors
Cold Spring Harbor Symposia on Quantitative Biology, 1994 Joan Massagué +6 more
openaire +3 more sources
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, EarlyView.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley +1 more source
Demonstration of proliferating cell nuclear antigen (PCNA/Cyclin) in glioma cells.
, 1987 Kazuo Tabuchi +2 more
openalex +2 more sources
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. [PDF]
, 1994 Masanori Hatakeyama +3 more
openalex +1 more source
Growth Charts for Children With Beckwith–Wiedemann Spectrum
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Beckwith–Wiedemann spectrum (BWSp) is an overgrowth disorder caused by (epi)genetic alterations in chromosome 11p15. This study aimed to develop BWSp‐specific growth charts and explore genotype/phenotype correlations with respect to growth. Heights, weights, and head circumferences were retrospectively collected from 581 individuals with BWSp ...
Saskia M. Maas +11 more
wiley +1 more source