Results 181 to 190 of about 230,940 (319)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2 [PDF]

, 1993
Barbara Faha, E Harlow, Emma Lees
openalex   +1 more source

Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or ‐resistant myeloma cells

Hematological Oncology, Volume 40, Issue 5, Page 999-1008, December 2022., 2022
Abstract Mechanisms underlying interactions between a novel, clinically relevant circularized tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) agonist, circularly permuted TRAIL (CPT) have been examined in multiple myeloma (MM) cells sensitive or resistant to bortezomib (BTZ).
Yun Leng, Xiaoyan Hu, Lin Li, Jewel Nkwocha, Toshihisa Satta, Kanika Sharma, Maciej Kmeiciak, Huixing Zhou, Zhiyao Zhang, Liang Zhou, Wenming Chen, Steven Grant   +11 more
wiley   +1 more source

Plasticity of mitotic cyclins in promoting the G2-M transition. [PDF]

J Cell Biol
Crncec A, Lau HW, Ng LY, Ma HT, Mak JPY, Choi HF, Yeung TK, Poon RYC.   +7 more
europepmc   +1 more source

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

, 1993
Yan Geng, Robert A. Weinberg
openalex   +1 more source

Systemic circulating microRNA landscape in Lynch syndrome

International Journal of Cancer, Volume 152, Issue 5, Page 932-944, 1 March 2023., 2023
What's new? Systemic circulating microRNA expression patterns (c‐miRnomes) are altered during sporadic carcinogenesis and they have predictive potential in early cancer detection. However, their potential in carriers of inherited pathogenic mismatch‐repair gene variants associated with Lynch syndrome remains understudied.
Tero Sievänen, Tia‐Marje Korhonen, Tiina Jokela, Maarit Ahtiainen, Laura Lahtinen, Teijo Kuopio, Anna Lepistö, Elina Sillanpää, Jukka‐Pekka Mecklin, Toni T. Seppälä, Eija K. Laakkonen   +10 more
wiley   +1 more source

Cyclin E1 overexpression triggers interferon signaling and is associated with antitumor immunity in breast cancer. [PDF]

J Immunother Cancer
Yu S, Stappenbelt C, Chen M, Dekker M, Bhattacharya A, van der Sluis T, Zwager MC, Schröder CP, Fehrmann RSN, van Vugt MATM, van der Vegt B.   +10 more
europepmc   +1 more source

The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.

, 1990
William G. F. Whitfield, Cayetano González, Gabriela Maldonado-Codina, David M. Glover   +3 more
openalex   +1 more source

Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
wiley   +1 more source

Simultaneous cyclin D1 overexpression and p27^kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina. [PDF]

Elife
Wu Z, Liao B, Ying J, Keung J, Zheng Z, Ahola V, Xiong W.   +6 more
europepmc   +1 more source