Results 181 to 190 of about 241,661 (217)

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Regulation of TIPIN and replication fork dynamics by USP37. [PDF]

Mol Biol Cell
Stromberg BR, Scarberry L, Cho IS, Summers MK.   +3 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Progesterone Is Associated With Increased Vasohibin-2 Expression, Tubulin Detyrosination, and Paclitaxel Sensitivity in PR-Negative Ovarian Cancer Cells. [PDF]

Cancer Rep (Hoboken)
Koyanagi T, Saga Y, Takahashi Y, Tamura K, Suizu E, Yamamoto K, Taneichi A, Takei Y, Mizukami H, Fujiwara H.   +9 more
europepmc   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

In-depth examination of the zinc-mitigation of the molecular effects of heat stress-induced intestinal damage in broilers. [PDF]

Poult Sci
Hu Y, Hu Y, Lin X, Liu HC, Odle J, See MT, Zhang L, Luo X.   +7 more
europepmc   +1 more source

Estradiol Promotes Tumor Progression in ERα-Low Endometrial Cancer via the GPER/SphK1 Pathway. [PDF]

J Biochem Mol Toxicol
Wang X, Sun H, Wen X, Xin W, Hu Z, Zhao Z, Zhang L.   +6 more
europepmc   +1 more source

Stage-Specific Degradation of Cyclin D3 Orchestrates Myelopoiesis and Restrains Myeloproliferative Neoplasm Development. [PDF]

Cancer Res
Mucha B, Tarallo V, Abbas A, Hall M, Zhang S, Farago M, Phillips-Mason PJ, Lindley H, Cameron M, Zhao C, Desai AB, Diehl JA.   +11 more
europepmc   +1 more source

Correction. [PDF]

Cell Cycle
europepmc   +1 more source