Results 141 to 150 of about 240,615 (263)

Cyclin [PDF]

, 2020
openaire   +1 more source

MAD2L1 overexpression promotes breast cancer progression and confers resistance to paclitaxel via proteasomal stabilization. [PDF]

Oncol Lett
Wang SH, Yeh CH, Wu CW, Hsu CY, Tsai EM, Hung CM, Lin MW, Hsieh TH.   +7 more
europepmc   +1 more source

Electroclinical phenotypes—genetic characterization of developmental and epileptic encephalopathies in a cohort study

Epileptic Disorders, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman, Fulya Kurekci, Sinan Akbas, Ceyda Oney, Mehmet Akif Kilic, Hulya Maras Genc, Ayca Dilruba Aslanger, Edibe Pembegul Yildiz   +7 more
wiley   +1 more source

SCML2 inhibits PrimPol-mediated DNA replication repriming and regulates replication gap-associated cancer cell vulnerability. [PDF]

Sci Adv
Shi X, Peng Q, Guo J, Wu W, Wang P, Zhou X, Chen Q.   +6 more
europepmc   +1 more source

Do preclinical seizure models predict success or failure in anti‐seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy

Epilepsia, EarlyView.
Abstract Anti‐seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection.
Wolfgang Löscher, Melissa Barker‐Haliski   +1 more
wiley   +1 more source

Spatiotemporal Redox Regulation of Cell-Cycle Progression: Dynamic Functions of Cellular Redox Regulatory Proteins. [PDF]

Cells
Patwardhan RS, Morjaria S, Nandi G, Hasan S, Sandur SK.   +4 more
europepmc   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Correction for Tsang et al., Cyclin D1 overexpression supports stable EBV infection in nasopharyngeal epithelial cells. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

cAMP Analogs Induce p53-independent p21 Expression through Sp1-responsive Promoter Activation and p300-associated Epigenetic Regulation in PC-3 Human Prostate Cancer Cells. [PDF]

J Cancer Prev
Hwangbo H, Kim SO, Jeong SJ, Hong SH, Choi YH.   +4 more
europepmc   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source