The Role of Cyclin D3-dependent Kinase in the Phosphorylation of p130 in Mouse BALB/c 3T3 Fibroblasts [PDF]
, 1998 Feng Dong +3 more
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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2010 Background and objective cyclin D1 is a member of the cyclin family, and it has been proven that it plaied an important role in tumorigenesis, invasion and metastasis.
Jiping ZHU +4 more
doaj
Targeting CDK6 and BCL2 Exploits the MYB Addiction of Ph+ Acute Lymphoblastic Leukemia [PDF]
, 2018 Philadelphia chromosome–positive acute lymphoblastic leukemia (Phþ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1–dependent and –
Addya, Sankar +12 more
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Supplementary Figure 2 from Loss of Cdk2 and Cyclin A2 Impairs Cell Proliferation and Tumorigenesis [PDF]
, 2023 Lakshmi Gopinathan +5 more
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Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Bifurcation analysis of a model of the budding yeast cell cycle
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core +1 more source
Isolation and Characterization of the cDNA for an A-like Cyclin in Adiantum capillus-veneris L. [PDF]
, 1996 K. Uchida +4 more
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Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
Advanced Science, EarlyView.This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
Cyclin D1/PRAD1/BCL‐1 alternative transcript [B] protein product in B‐lymphoid malignancies with t(11;14)(q13;q32) translocation [PDF]
, 1999 Yoshitaka Hosokawa +4 more
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