Results 171 to 180 of about 240,615 (263)

NUPR1 inhibition prevents mitotic catastrophe: a novel therapeutic strategy for podocyte injury in diabetic kidney disease. [PDF]

Cell Death Dis
Cai Y, Zhang L, Li L, Wang W, Chen Y, Zhao X, Li J, Wen J, Li D, Xiao M, Li R, Liang X.   +11 more
europepmc   +1 more source

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

Collision of Malignant Melanoma and Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia: A Case Report and Literature Review. [PDF]

Dermatopathology (Basel)
Zhou J, Cruthirds L, Cornelius E, Howard JH, Knowles K.   +4 more
europepmc   +1 more source

Cytotoxic and Pro‐Apoptotic Effects of the Compound 2‐Carboxy‐2‐Heptano‐Indolin‐3‐One in HeLa Cell Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Indolinones are compounds with recognized antineoplastic properties and can act as inhibitors of multiple kinases. However, the antitumor effects of 2‐carboxy‐2‐heptano‐indolin‐3‐one (IDC) have not yet been investigated in cervical cancer models.
Agda Lorena Corrêa Rocha, Caroline Fernandes Westin, Erika Tyemi Goya Niekawa, Galdino Andrade, Luan Vitor Alves de Lima, Lucas Karpinski Risson, Matheus Felipe da Silva, Stefani Fabiola Alarcon, Mário Sérgio Mantovani   +8 more
wiley   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

The Role of Transcriptional and Atypical Cyclin-Dependent Protein Kinases in Melanoma. [PDF]

Cancers (Basel)
Kaszubski J, Gagat M, Wawrzyniak A, Żuryń A.   +3 more
europepmc   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source

Overcoming Docetaxel Resistance in Prostate Cancer by Targeting Cell Cycle Progression with Narciclasine-Based Compounds. [PDF]

ACS Omega
Silva Machado R, S Gomes K, B Farias A, Meneses Araújo N, Barbosa Chanes G, Pinto Dias LM, Zaia Franco Ferreira B, Lopes CC, Rubio IGS, Moreira Simabuco F, G G Rando D, Pequeno Monteiro H, Garcia Erustes A, Smaili SS, Ryffel D, Sarlah D, Cerchiaro G, Lago JHG, Tamura RE.   +18 more
europepmc   +1 more source

DARS2 Promotes Tumorigenesis and Metastasis by Activating PI3K/Akt/GSK‐3β/β‐Catenin Signaling Pathway in Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Aspartyl‐tRNA synthetase 2 (DARS2), the mitochondrial enzyme responsible for aminoacylation of aspartyl‐tRNA, is traditionally known for its effect on protein synthesis. Recently, DARS2 is reported to be implicated in tumorigenesis. However, its specific effect on breast cancer (BC) is poorly understood.
Na Wang, Ming Huang
wiley   +1 more source

Identification and Biological Evaluation of Fisetin as a Novel DYRK1B Inhibitor in Ovarian Cancer with Apoptotic and Ferroptotic Effects. [PDF]

Drug Des Devel Ther
Sam A, Peng CH, Hsu KC, HuangFu WC.
europepmc   +1 more source