Results 181 to 190 of about 406,416 (358)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Protein inhibitor of activated STAT xα depresses cyclin D and cyclin D kinase, and contributes to the inhibition of osteosarcoma cell progression

, 2015
Junjie Wang, Jiangdong Ni, Shuai Yi, Deye Song, Muliang Ding   +4 more
openalex   +2 more sources

Data from Expression of p16^Ink4a Compensates for <i>p18^Ink4c</i> Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues

, 2023
Matthew R. Ramsey, Janakiraman Krishnamurthy, Xin‐Hai Pei, Chad Torrice, Weili Lin, Daniel R. Carrasco, Keith L. Ligon, Yue Xiong, Norman E. Sharpless   +8 more
openalex   +1 more source

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Data from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma

, 2023
Angela Bik‐Yu Hui, Yvonne Yan‐Yan Or, Hirokuni Takano, Raymond King‐Yin Tsang, Ka‐Fai To, Xin-Yuen Guan, Jonathan S. T. Sham, Katherine Wing-Ki Hung, Cleo Nga-Yee Lam, C. Andrew van Hasselt, Wen-Lin Kuo, Joe W. Gray, Dolly P. Huang, Kwok Wai Lo   +13 more
openalex   +1 more source

Prognostic Significance of Portal Vein Tumor Thrombus in Pancreatic Ductal Adenocarcinoma Treated With Chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To examine the significance of portal vein tumor thrombus (PVTT) as a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC) treated with chemoradiotherapy (CRT) followed by surgery. Methods The study retrospectively examined 313 patients with borderline resectable (BR) or locally advanced (LA) PDAC who underwent CRT ...
Aoi Hayasaki, Motonori Nagata, Miki Usui, Hiroshi Imai, Yusuke Iizawa, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno   +9 more
wiley   +1 more source

Data from Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK–LKB1 Signaling Axis

, 2023
Mathew C. Casimiro, Gabriele Di Sante, Agnese Di Rocco, Emanuele Loro, Claudia Pupo, Timothy G. Pestell, Sara Bisetto, Marco A. Velasco‐Velázquez, Xuanmao Jiao, Zhiping Li, Christine M. Kusminski, Erin L. Seifert, Chenguang Wang, Daniel Ly, Bin Zheng, Che‐Hung Shen, Philipp E. Scherer, Richard G. Pestell   +17 more
openalex   +1 more source

Supplementary Figure 2 from PAI-1 Leads to G₁-Phase Cell-Cycle Progression through Cyclin D3/cdk4/6 Upregulation [PDF]

, 2023
Evan Gomes Giacoia, Makito Miyake, Adrienne Lawton, Steve Goodison, Charles J. Rosser   +4 more
openalex   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Data from The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates the Effects of Topoisomerase I Poisons by Suppressing Rad51 Expression in a p53-Dependent Manner

, 2023
Grazia Ambrosini, Sharon L. Seelman, Li‐Xuan Qin, Gary K. Schwartz   +3 more
openalex   +1 more source