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Cyclins, cyclin‐dependent kinases and differentiation
BioEssays, 1997AbstractCyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate progression through the cell cycle. Yet these same proteins are often expressed in non‐cycling, differentiated cells. This review surveys the available information about cyclins and cyclin‐dependent kinases in differentiated cells and explores the ...
Chun Y. Gao, Peggy S. Zelenka
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Trends in Cell Biology, 1992
Cyclins are regulatory subunits of the serine/threonine protein kinases that play key roles in cell cycle control. The roster of known cyclins has expanded significantly in the past year, revealing a large and very diverse family of proteins. Although cyclins were originally characterized by their periodic accumulation during interphase and destruction
Steven I. Reed, Daniel J. Lew
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Cyclins are regulatory subunits of the serine/threonine protein kinases that play key roles in cell cycle control. The roster of known cyclins has expanded significantly in the past year, revealing a large and very diverse family of proteins. Although cyclins were originally characterized by their periodic accumulation during interphase and destruction
Steven I. Reed, Daniel J. Lew
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Molecular Neurobiology, 2020
Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiescent or differentiate. The underlying
Alice Grison +2 more
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Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiescent or differentiate. The underlying
Alice Grison +2 more
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The International Journal of Biochemistry & Cell Biology, 2004
E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. The activity of cyclin E is limiting for the passage of cells through the restriction point "R" which marks a "point of no return" for cells entering the division cycle from a resting state or passing from G1 into S-phase ...
Tarik, Möröy, Christoph, Geisen
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E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase. The activity of cyclin E is limiting for the passage of cells through the restriction point "R" which marks a "point of no return" for cells entering the division cycle from a resting state or passing from G1 into S-phase ...
Tarik, Möröy, Christoph, Geisen
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Reviews in Medical Virology, 2000
Cyclins are regulatory subunits of the cyclin-dependent protein kinases (CDKs). Members of this serine-threonine kinase family regulate the progression of cells through the division cycle. Until some years ago, cyclins were presumed to be encoded exclusively by eukaryotic cells.
S, Mittnacht, C, Boshoff
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Cyclins are regulatory subunits of the cyclin-dependent protein kinases (CDKs). Members of this serine-threonine kinase family regulate the progression of cells through the division cycle. Until some years ago, cyclins were presumed to be encoded exclusively by eukaryotic cells.
S, Mittnacht, C, Boshoff
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Neuroscience Letters, 2003
Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have ...
FIANO, VALENTINA +2 more
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Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have ...
FIANO, VALENTINA +2 more
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Breast Cancer Research and Treatment, 1998
Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections,
Qun Zhou, Patricia S. Steeg
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Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections,
Qun Zhou, Patricia S. Steeg
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Cyclins and Cyclin-Dependent Kinases: Theme and Variations
1995Publisher Summary This chapter introduces cyclins and their partner—cyclin dependent kinases (CDKs)—and the ways in which CDK complexes can be regulated. Cyclins are intimately concerned with regulating and coordinating deoxyribonucleic acid (DNA) replication and cell division.
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Cyclin A and cyclin B1 overexpression in differentiated thyroid carcinoma
Medical Oncology, 2011Approximately 30% of patients with thyroid nodules have indeterminate or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic value of cyclin A and cyclin B1 immunohistochemistry added to routine cytology and their expression on histological ...
Asli Nar +3 more
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Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Nature, 2005Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. Different cyclins promote distinct cell-cycle events, but the molecular basis for these differences remains unclear. Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in ...
Mart Loog, David O. Morgan
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