Results 41 to 50 of about 2,773,799 (223)
The Function and Molecular Mechnism of Cyclin Y Protein
Chinese Journal of Lung Cancer, 2013 A novel cyclin, cyclin Y, is one of the most highly conserved members of the cyclin superfamily, which is famous for their important roles in regulating the cell cycle and transcription.
Xiaoting ZHAO, Mei JIANG, Wentao YUE
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Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
eLife, 2023 Cyclin D1 is a key regulator of cell cycle progression, which forms a complex with CDK4/6 to regulate G1/S transition during cell cycle progression.
Ke Lu +5 more
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Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations [PDF]
Journal of Medicinal Chemistry 49, 5141-5153 (2006), 2008 The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to ...
arxiv +1 more source
The Cyclin-Dependent Kinase Ortholog pUL97 of Human Cytomegalovirus Interacts with Cyclins
Viruses, 2013 The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics.
Laura Graf +6 more
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Cellular Oncology, 2006 Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3 and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle propulsion and are not previously ...
A. Husdal, G. Bukholm, I. R. K. Bukholm
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Immunohistochemical analysis of cyclin A expression in Wilms tumor [PDF]
PeerJ, 2019 Background Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative ...
Sanja Radojević-Škodrić +9 more
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Cyclin-dependent kinases [PDF]
Genome Biology, 2014 SummaryCyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues.
openaire +3 more sources
Cytometry of cyclin proteins [PDF]
Cytometry, 1996 Cyclins are key components of the cell cycle progression machinery. They activate their partner cyclin-dependent kinases (CDKs) and possibly target them to respective substrate proteins within the cell. CDK-mediated phosphorylation of specific sets of proteins drives the cell through particular phases or checkpoints of the cell cycle.
Jianping Gong +4 more
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Biology, 2022 Cyclin-like genes are primarily considered as cell cycle regulators and have shown to be crucial for insect growth, development, reproduction, and fertility.
Muhammad Asad +5 more
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OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials [PDF]
arXiv, 2023 Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy.
arxiv