Results 131 to 140 of about 12,781,724 (361)

Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells. [PDF]

, 2016
BackgroundWilms' tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene ...
Ampasavate, Chadarat, Anuchapreeda, Songyot, Katekunlaphan, Trinnakorn, Okonogi, Siriporn, Rungrojsakul, Methee, Saiai, Aroonchai, Sweeney, Colleen A   +6 more
core   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1

BMC Research Notes, 2011
Background The elongation phase, like other steps of transcription by RNA Polymerase II, is subject to regulation. The positive transcription elongation factor b (P-TEFb) complex allows for the transition of mRNA synthesis to the productive elongation ...
Yu Wendong, Ramakrishnan Rajesh, Rice Andrew P   +2 more
doaj   +1 more source

Supplementary Figure 1 from Cyclin D1 Inhibits Mitochondrial Activity in B Cells [PDF]

, 2023
Guergana Tchakarska, Mikaël Roussel, Xavier Troussard, Brigitte Sola   +3 more
openalex   +1 more source

M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]

, 2019
Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao, Gao, Fei, Huang, Dong, Huang, Jun-Yong, Jowsey, Paul, Li, Jianquan, Lightowlers, Robert N., Martinez-Lopez, Nuria   +7 more
core   +1 more source

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

Prognostic Value of Cyclin D1 Overexpression in Invasive Breast Carcinoma

Trends in Surgical Sciences
Objective: Breast cancer is the most diagnosed cancer worldwide, accounting for 11.7% of all cancers. Cyclin D1, a regulator of CDK4/6 and cell cycle progression, functions as an oncogene through overexpression, contributing to the pathogenesis of ...
Funda Taşlı, Enver Vardar, Ayşe Yağcı, Demet Kocatepe Çavdar, Erdem Çomut   +4 more
doaj   +1 more source

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression

Cell Reports, 2018
Summary: Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase.
Ioanna Mavrommati, Roberta Faedda, Giovanni Galasso, Jie Li, Kamila Burdova, Roman Fischer, Benedikt M. Kessler, Zunamys I. Carrero, Daniele Guardavaccaro, Michele Pagano, Vincenzo D’Angiolella   +10 more
doaj   +1 more source

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase

, 2021
Belén Martínez-Gualda, Sirle Saul, Matheus Froeyen, Dominique Schols, Piet Herdewijn, Shirit Einav, Steven De Jonghe   +6 more
openalex   +2 more sources

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source