Results 191 to 200 of about 13,222,515 (326)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation

Advanced Science, EarlyView.
Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Hongli Yin, Wenjuan Tang, Danqing Huang, JingJing Gan, Pengzi Zhang, Yuanjin Zhao, Yan Bi   +6 more
wiley   +1 more source

Two-Step Mechanism of Cyclin B Degradation Initiated by Proteolytic Cleavage with the 26 S Proteasome in Fish. [PDF]

Sci Rep, 2020
Tokumoto T, Hossain MF, Jyoti MMS, Ali MH, Hossain MB, Acharjee M, Rezanujjaman M, Tokumoto M.   +7 more
europepmc   +1 more source

Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

Advanced Science, EarlyView.
In this study, it is found that osteoporosis leads to disturbances in the Extracellular Matrix (ECM)of tendons and thus causes a decrease in TSPC stemness, resulting in a rotator cuff that is easily damaged and prone to retearing after repair. Targeted intervention with si‐CD248‐loaded liposomes can restore TSPC stemness, promote tendon‐bone healing ...
Yinhua Qian, Jinguo Zhu, Yanwei He, Haocheng Qin, Pingkang Qian, Bingfeng Sun, Haoqiang Huang, Chen Kuang, Quan Yang, Yuxi Ou, Rong Sun, Feng Xu, Xianwen Wang, Zhiwen Luo, Qing Wang   +14 more
wiley   +1 more source

CDK activity at the centrosome regulates the cell cycle

Cell Reports
Summary: In human cells and yeast, an intact “hydrophobic patch” substrate docking site is needed for mitotic cyclin centrosomal localization. A hydrophobic patch mutant (HPM) of the fission yeast mitotic cyclin Cdc13 cannot enter mitosis, but whether ...
Emma L. Roberts, Jessica Greenwood, Nitin Kapadia, Tania Auchynnikava, Souradeep Basu, Paul Nurse   +5 more
doaj  

Introduction of Cyclin B Induces Activation of the Maturation-Promoting Factor and Breakdown of Germinal Vesicle in Growing Zebrafish Oocytes Unresponsive to the Maturation-Inducing Hormone

, 1997
Tomoko Kondo, Toshiharu Yanagawa, Noriyuki Yoshida, Masakane Yamashita   +3 more
openalex   +1 more source

Evidence for a role of the α-tubulin C terminus in the regulation of cyclin B synthesis in developing oocytes [PDF]

, 2001
Sophie Vée, Laurence Lafanéchère, Daniel Fisher, Jürgen Wehland, Didier Job, André Picard   +5 more
openalex   +1 more source

Phosphorylation and activation of human cdc25‐C by cdc2‐‐cyclin B and its involvement in the self‐amplification of MPF at mitosis.

EMBO Journal, 1993
I. Hoffmann, P. Clarke, M. J. Marcote, E. Karsenti, G. Draetta   +4 more
semanticscholar   +1 more source

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing. [PDF]

Nat Commun
Ng HY, Whelpley DH, Adly AN, Maxwell RA, Morgan DO.   +4 more
europepmc   +1 more source