Results 191 to 200 of about 13,616,352 (396)

Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]

, 2014
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura, Cayrol, Maria Florencia, Colombo, L., Cremaschi, Graciela Alicia, Díaz Flaqué, María Celeste, Klecha, Alicia Juana, Martinel Lamas, Diego José, Medina, Vanina Araceli, Paulazo, Maria Alejandra, Sterle, Helena Andrea, Valli, Eduardo   +10 more
core   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt’s lymphoma

Haematologica, 2009
Background We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1.Design and Methods On hundred and seventy-two specimens were immunostained for the SOX11
Michael Dictor, Sara Ek, Maria Sundberg, Janina Warenholt, Czabafy György, Sandra Sernbo, Elin Gustavsson, Waleed Abu-Alsoud, Torkel Wadström, Carl Borrebaeck   +9 more
doaj   +1 more source

Control of division in Chlamydomonas by cyclin B/CDKB1 and the anaphase-promoting complex. [PDF]

PLoS Genet, 2022
Pecani K, Lieberman K, Tajima-Shirasaki N, Onishi M, Cross FR.   +4 more
europepmc   +1 more source

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]

, 2017
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara, Casimiro, Mathew C., Di Rocco, Agnese, Disante, Gabriele, Jiao, Xuanmao, Kusminski, Christine M., Li, Zhiping, Loro, Emanuele, Ly, Daniel, Pestell, Richard, Pestell, Timothy G., Pupo, Claudia, Scherer, Philipp E., Seifert, Erin L., Shen, Che-Hung, Velasco-Velázquez, Marco A., Wang, Chenguang, Zheng, Bin   +17 more
core   +1 more source

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2. [PDF]

, 1992
Helena E. Richardson, Daniel J. Lew, Martha Henze, Katsunori Sugimoto, Steven I. Reed   +4 more
openalex   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

The HIPK2/CDC14B-MeCP2 axis enhances the spindle assembly checkpoint block by promoting cyclin B translation. [PDF]

Sci Adv, 2023
Partscht P, Simon A, Chen NP, Erhardt S, Schiebel E.   +4 more
europepmc   +1 more source

A Novel OsMPK6‐OsMADS47‐PPKL1/3 Module Controls Grain Shape and Yield in Rice

Advanced Science, EarlyView.
OsMADS47 is identified as a key regulator governing rice grain morphology. Phosphorylation‐dependent regulation of its activity directs the development of slender versus round grains, modulating both yield and appearance. This mechanism bridges cellular signaling with transcriptional regulation, establishing a molecular framework for grain optimization.
Jingjing Fang, Yan Chun, Fan Zhang, Tingting Guo, Mengmeng Ren, Jinfeng Zhao, Shoujiang Yuan, Wensheng Wang, Yunhai Li, Xueyong Li   +9 more
wiley   +1 more source

Sharp Bounds for Neuman Means in Terms of Geometric, Arithemtic and Quadratic Means [PDF]

arXiv, 2014
In this paper, we find the greatest values $\alpha_{1}$, $\alpha_{2}$, $\alpha_{3}$, $\alpha_{4}$, $\alpha_{5}$, $\alpha_{6}$, $\alpha_{7}$, $\alpha_{8}$ and the least values $\beta_{1}$, $\beta_{2}$, $\beta_{3}$, $\beta_{4}$, $\beta_{5}$, $\beta_{6}$, $\beta_{7}$, $\beta_{8}$ such that the double inequalities $$A^{\alpha_{1}}(a,b)G^{1-\alpha_{1}}(a,b)<
arxiv