Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly
Cytoskeleton, EarlyView.ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley +1 more source
Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma
ChemMedChem, Accepted Article.Glioblastoma (GBM) is the most common and aggressive malignant grade IV brain tumour and is one of the most difficult types of brain cancer to treat with a high incidence of resistance to traditionally used chemotherapeutics. Pyrazolopyrimidinones are fused nitrogen‐containing heterocyclic systems which are a scaffold in several bioactive drugs and ...
Kate Byrne +5 more
wiley +1 more source
Bioinformatics analysis of immune‐programmed cell death‐related genes in nasopharyngeal carcinoma
Eye &ENT Research, EarlyView.Abstract Background Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor of the head and neck, characterized by a complex pathogenesis. Most newly diagnosed NPC patients are locally advanced, and 20%–30% of advanced NPC patients have poor immunotherapy results.
Hongqiang Chen +3 more
wiley +1 more source
Statement of Retraction: Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2α/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis. [PDF]
Cell Cycleeuropepmc +1 more source
Artemis Links ATM to G2/M Checkpoint Recovery via Regulation of Cdk1-Cyclin B
Molecular and Cellular Biology, 2007 L. Geng +3 more
semanticscholar +1 more source
DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids
European Journal of Organic Chemistry, Accepted Article.This report describes a general and simple method for the one‐pot direct N‐acylation of sulfoximines with carboxylic acids using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. The method can be performed under mild low‐temperature reaction conditions and has a wide substrate scope.
Atsushi Umehara +2 more
wiley +1 more source
HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins
Oncogene, 2007 Mahendra K. Singh +6 more
semanticscholar +1 more source
Problem‐solving test: Analysis of the role of cyclin B [PDF]
Biochemistry and Molecular Biology Education, 2011 openaire +3 more sources
Critical Evaluation of Methods for the Identification of Aneugens
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun +8 more
wiley +1 more source