Results 291 to 300 of about 13,222,515 (326)

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

SLC1A5-dependent glutamine uptake in hepatocytes promotes liver regeneration. [PDF]

Hepatol Commun
Duan Y, Peng S, Yue J, Ding F, Chen X, Pan W, Gao X, Pang P, Zhang Y, Wu W, Schneider KM, Cubero FJ, Trautwein C, Zhang L, Zhang Y, Liu J, Zhao G.   +16 more
europepmc   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor. [PDF]

Sci Adv
Wang Y, Liu M, Wang S, Mai X, Wang X, Teng F, Lyu T, Su MY, Stjepanovic G.   +8 more
europepmc   +1 more source

Spatiotemporal orchestration of mitosis by cyclin-dependent kinase. [PDF]

Nature
Kapadia N, Nurse P.
europepmc   +1 more source

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS-Dependent PTEN/AKT1 Signaling. [PDF]

Cancer Med
Jiang C, Wang C, Ao J, Liu Y, Sun F, Shi W, Guo Z, Wu Y, Gan L, Wu M, Zhi Y, Meng Z, Wu W, Wu J, Ye Y, Zhang X, Ren D, Pan M.   +17 more
europepmc   +1 more source

A novel peptide 66CTG stabilizes Myc proto-oncogene protein to promote triple-negative breast cancer growth. [PDF]

Signal Transduct Target Ther
Liang H, Li F, Fang H, Ren W, Zhou Z, Wang J, Liu J, Tang Y, Liu X, Wu Y, Peng J, Yang C, Chen J, Fei Y, Shi Y, Jiang D, Zhang N, Chen C.   +17 more
europepmc   +1 more source

E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells. [PDF]

Nat Commun
Kim K, Armand J, Kim S, Yang HW.
europepmc   +1 more source

Heat stress affects expression levels of circadian clock gene Bmal1 and cyclins in rat thoracic aortic endothelial cells. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Chang X, Zhang H, Cao H, Hou L, Meng X, Tao H, Luo Y, Li G.   +7 more
europepmc   +1 more source