eIF4A inhibitors suppress cell-cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer [PDF]
, 2019 CDK4/6 inhibitors are FDA-approved drugs for estrogen receptor-positive (ER+) breast cancer and are being evaluated to treat other tumor types, including KRAS-mutant non-small cell lung cancer (NSCLC).
Cencic, Regina +13 more
core +1 more source
Cyclin B–Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase–independent mechanism
Journal of Cell Biology, 2014 The role of Greatwall kinase in autoregulatory activation of cyclin B–Cdk1 at M phase onset can be bypassed by cyclin B–Cdk1–mediated direct phosphorylation of Arpp19, leading to PP2A-B55 inhibition.
E. Okumura +5 more
semanticscholar +1 more source
Characterization and localization of cyclin B3 transcript in both oocyte and spermatocyte of the rainbow trout (Oncorhynchus mykiss) [PDF]
PeerJ, 2019 B-type cyclins are regulatory subunits with distinct roles in the cell cycle. To date, at least three subtypes of B-type cyclins (B1, B2, and B3) have been identified in vertebrates. Previously, we reported the characterization and expression profiles of
Wenzhi Guan +5 more
doaj +2 more sources
Cyclin D3 expression in non-Hodgkin lymphoma. Correlation with other cell cycle regulators and clinical features [PDF]
, 2001 Udgivelsesdato: 2001-MarCyclin D3 is the most widely expressed D-type cyclin and can be rate limiting for G1/S transition. To study the expression of cyclin D3 in non-Hodgkin lymphoma, samples from 198 previously untreated patients with lymphoma from a ...
Møller, Michael Boe +2 more
core +1 more source
Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly
Journal of Cell Science, 2013 Summary Mitotic spindle assembly in animal cells is orchestrated by a chromosome-dependent pathway that directs microtubule stabilization. RanGTP generated at chromosomes releases spindle assembly factors from inhibitory complexes with importins, the ...
Zhige Wu +3 more
semanticscholar +1 more source
Cycling through mammalian meiosis: B-type cyclins in oocytes [PDF]
Cell Cycle, 2019 B-type cyclins in association with Cdk1 mediate key steps of mitosis and meiosis, by phosphorylating a plethora of substrates. Progression through the meiotic cell cycle requires the execution of two cell divisions named meiosis I and II without intervening S-phase, to obtain haploid gametes.
Bouftas, Nora, Wassmann, Katja
openaire +3 more sources
Biomolecules, 2021 Botryococcus braunii produce liquid hydrocarbons able to be processed into combustion engine fuels. Depending on the growing conditions, the cell doubling time can be up to 6 days or more, which is a slow growth rate in comparison with other microalgae ...
Xochitl Morales-de la Cruz +6 more
doaj +1 more source
Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation [PDF]
Oncogene, 2015 BRCA2 has an important role in the maintenance of genome stability by interacting with RAD51 recombinase through its C-terminal domain. This interaction is abrogated by cyclin A-CDK2-mediated phosphorylation of BRCA2 at serine 3291 (Ser3291). Recently, we showed that cyclin D1 facilitates RAD51 recruitment to BRCA2-containing DNA repair foci, and that ...
C, Chalermrujinanant +4 more
openaire +2 more sources
Distinct and Overlapping Requirements for Cyclins A, B, and B3 in Drosophila Female Meiosis
G3: Genes, Genomes, Genetics, 2016 Meiosis, like mitosis, depends on the activity of the cyclin dependent kinase Cdk1 and its cyclin partners. Here, we examine the specific requirements for the three mitotic cyclins, A, B, and B3 in meiosis of Drosophila melanogaster.
Mohammed Bourouh +5 more
doaj +1 more source
Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]
, 2010 Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad +6 more
core +5 more sources