Results 41 to 50 of about 470,056 (173)
Bifurcation analysis of a model of the budding yeast cell cycle [PDF]
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae. We show that Clb2-dependent kinase exhibits bistability (stable steady states of high or low kinase activity).
arxiv +1 more source
Cyclins A, B, E and p27 in Endometrial Endometrioid Adenocarcinoma [PDF]
Anticancer Research, 2016 We have previously shown that cyclin A, B and E hold prognostic significance in endometrial endometrioid adenocarcinoma. The aim of this study was to investigate the impact of cyclin-dependent kinase inhibitor p27 on cancer-specific survival and other clinicopathological variables, as well as further analyze the relationship between p27 and cyclins A ...
Ylermi Soini +5 more
openaire +2 more sources
Overexpression of cyclin D2 in chronic B-cell malignancies [PDF]
Blood, 1995 Tumor progression in B-cell chronic lymphocytic leukemia (B-CLL) is thought to result from the gradual accumulation of small resting G0/G1 phase lymphoid cells rather than the proliferation of actively dividing cells. The recent identification of G1 cyclins that are likely to control both the progression through G0 and G1 phase and the G1/S transition ...
Sylvie Ramond +6 more
openaire +3 more sources
The Journal of Cell Biology, 2003 ![Graphic][1] Though normally cytoplasmic (left), cyclin B (red) targeted to the nucleus (right) can start S phase. Hunt/AAASIn mammalian cells the work of the cell cycle is divided between two workhorses: Cdk2/cyclin E for S phase and Cdk1/cyclin B for mitosis. Now, Jonathan Moore,
openaire +3 more sources
The Kinetics of G2 and M Transitions Regulated by B Cyclins
PLoS ONE, 2013 B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an optimization. To explore this idea, we generated HeLa BD™ Tet-Off cell lines with inducible cyclin B1-
Yehong Huang +2 more
openaire +5 more sources
OpenMM 8: Molecular Dynamics Simulation with Machine Learning Potentials [PDF]
arXiv, 2023 Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbitrary PyTorch models can be added to a simulation and used to compute forces and energy.
arxiv
Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction. [PDF]
The EMBO Journal, 1991 Previous work has established that destruction of cyclin B is necessary for exit from mitosis and entry into the next interphase. Sea urchin cyclin B lacking an N-terminal domain is stable, permanently activates cdc2 kinase, resulting in mitotic arrest, and permanently activates the destruction pathway acting on full length cyclin B.
F.C. Luca +3 more
openaire +3 more sources
AlphaFold Accelerates Artificial Intelligence Powered Drug Discovery: Efficient Discovery of a Novel Cyclin-dependent Kinase 20 (CDK20) Small Molecule Inhibitor [PDF]
arXiv, 2022 The AlphaFold computer program predicted protein structures for the whole human genome, which has been considered as a remarkable breakthrough both in artificial intelligence (AI) application and structural biology. Despite the varying confidence level, these predicted structures still could significantly contribute to structure-based drug design of ...
arxiv
Aurora B: Hooking up with cyclin-dependent kinases [PDF]
Cell Cycle, 2013 Aurora B (Aurkb) is one of the major protein kinases that ensures the proper execution and fidelity of mitosis.1 A member of the chromosomal passenger complex, Aurkb has been implicated in various mitotic functions, including chromosome-microtubule interactions, sister chromatid cohesion, the spindle-assembly checkpoint and cytokinesis.2 As it is ...
openaire +4 more sources
Cycline subalgebras of $k$-graph C*-algebras [PDF]
arXiv, 2015 In this paper, we prove that the cycline subalgbra of a $k$-graph C*-algebra is maximal abelian, and show when it is a Cartan subalgebra (in the sense of Renault).
arxiv