Results 41 to 50 of about 13,222,515 (326)
Cyclin B targets p34cdc2 for tyrosine phosphorylation. [PDF]
The EMBO Journal, 1991 A universal intracellular factor, the 'M phase-promoting factor' (MPF), triggers the G2/M transition of the cell cycle in all organisms. In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13.
L. Azzi, J. Y. J. Wang, Laurent Meijer
openaire +3 more sources
Cell Communication and Signaling, 2013 BackgroundSevere shortage of liver donors and hepatocytes highlights urgent requirement of extra-liver and stem cell source of hepatocytes for treating liver-related diseases.
Zhenzhen Zhang +11 more
semanticscholar +1 more source
A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. [PDF]
The EMBO Journal, 1993 Both cyclins A and B associate with and thereby activate cyclin-dependent protein kinases (cdks). We have investigated which component in the cyclin-cdk complex determines its substrate specificity. The A- and B-type cyclin-cdk complexes phosphorylated histone H1 and their cyclin subunits in an indistinguishable manner, irrespective of the catalytic ...
H. Piwnica-Worms +8 more
openaire +3 more sources
Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.
PLoS ONE, 2012 Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling
Mara E Robu, Yong Zhang, Jennifer Rhodes
doaj +1 more source
Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor
Nature Communications, 2012 Maturation/M-phase-promoting factor is the universal inducer of M-phase in eukaryotic cells. It is currently accepted that M-phase-promoting factor is identical to the kinase cyclin B–Cdk1. Here we show that cyclin B–Cdk1 and M-phase-promoting factor are
Masatoshi Hara +5 more
semanticscholar +1 more source
Journal of Biological Chemistry, 2012 Background: Pah1p, a phosphatidate phosphatase in yeast, produces diacylglycerol for lipid synthesis. Results: Phosphorylation of Pah1p by protein kinase A inhibited membrane association, phosphatidate phosphatase activity, and triacylglycerol synthesis.
Wen‐Min Su +3 more
semanticscholar +1 more source
Biomarker Research, 2019 Background A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. These cases usually lack of CCND1 gene rearrangement.
Da Gao, Zach Liu
doaj +1 more source
p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription. [PDF]
PLoS ONE, 2012 DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01).
Robert Lipski +6 more
doaj +1 more source
Exploring cell cycle-mediated regulations of glycolysis in budding yeast
Frontiers in Microbiology, 2023 Coordination of cell cycle with metabolism exists in all cell types that grow by division. It serves to build a new cell, (i) fueling building blocks for the synthesis of proteins, nucleic acids, and membranes, and (ii) producing energy through ...
Yanfei Zhang +4 more
doaj +1 more source
Whole-genome analysis of animal A- and B-type cyclins [PDF]
Genome Biology, 2002 Multiple A- and B-type cyclins have been identified in animals, but their study is complicated by varying degrees of functional redundancy. A non-essential phenotype may reflect redundancy with a known or as yet unknown gene. Complete sequencing of several animal genomes has allowed us to determine the size of the mitotic cyclin gene family and ...
Nieduszynski, Conrad A. +2 more
openaire +4 more sources