Results 51 to 60 of about 13,609,830 (345)
A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets [PDF]
arXiv, 2023 The regulatory mechanisms driving progression of the yeast cell cycle appears to be comprised of an interacting network of transcription factors (TFs), cyclin-dependent kinases (CDK) and ubiquitin ligases. From a systems perspective the controlling regulatory network must produce robust periodic behavior during proliferative phases, but have the ...
arxiv
A model for regulation of the cell cycle incorporating cyclin A, cyclin B and their complexes
Cell Proliferation, 1994 Abstract. t. A mathematical model for the cell cycle is proposed that incorporates the known biochemical reactions involving both cyclin A and cyclin B, the interactions of these cyclins with cdc2 and cdk2, and the controlling effects of cdc25 and weel.
Mandri N. Obeyesekere +2 more
openaire +3 more sources
Cyclin B targets p34cdc2 for tyrosine phosphorylation. [PDF]
The EMBO Journal, 1991 A universal intracellular factor, the 'M phase-promoting factor' (MPF), triggers the G2/M transition of the cell cycle in all organisms. In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13.
L. Azzi, J. Y. J. Wang, Laurent Meijer
openaire +3 more sources
Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.
PLoS ONE, 2012 Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling
Mara E Robu, Yong Zhang, Jennifer Rhodes
doaj +1 more source
p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription. [PDF]
PLoS ONE, 2012 DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01).
Robert Lipski +6 more
doaj +1 more source
PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
Frontiers in Oncology, 2022 PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba +6 more
doaj +1 more source
Cyclin D2 plays a regulatory role in HBV replication [PDF]
, 2014 Hepatitis B virus (HBV) infection is the leading cause of liver diseases. However, the molecular mechanisms of HBV infection and carcinogenesis have not been fully elucidated. In this study, we found that cyclin D2 was upregualted in HBV-expressing cells
Chen, Juan +8 more
core +1 more source
Cell Communication and Signaling, 2013 BackgroundSevere shortage of liver donors and hepatocytes highlights urgent requirement of extra-liver and stem cell source of hepatocytes for treating liver-related diseases.
Zhenzhen Zhang +11 more
semanticscholar +1 more source
Early transformation event from follicular lymphoma: our experience of four cases
Polish Journal of Pathology, 2022 Follicular lymphoma (FL) is a mature B-cell lymphoma that can transform into a more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation of FL occurs by
Anurag Mehta +2 more
doaj +1 more source
Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor
Nature Communications, 2012 Maturation/M-phase-promoting factor is the universal inducer of M-phase in eukaryotic cells. It is currently accepted that M-phase-promoting factor is identical to the kinase cyclin B–Cdk1. Here we show that cyclin B–Cdk1 and M-phase-promoting factor are
Masatoshi Hara +5 more
semanticscholar +1 more source