Results 51 to 60 of about 12,781,724 (361)

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

PLoS ONE, 2012
Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling
Mara E Robu, Yong Zhang, Jennifer Rhodes
doaj   +1 more source

p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription. [PDF]

PLoS ONE, 2012
DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01).
Robert Lipski, Daniel J Lippincott, Brittany C Durden, Anne R Kaplan, Hilary E Keiser, Jung-Ho Park, Aime A Levesque   +6 more
doaj   +1 more source

Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]

, 2014
We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura, Cayrol, Maria Florencia, Colombo, L., Cremaschi, Graciela Alicia, Díaz Flaqué, María Celeste, Klecha, Alicia Juana, Martinel Lamas, Diego José, Medina, Vanina Araceli, Paulazo, Maria Alejandra, Sterle, Helena Andrea, Valli, Eduardo   +10 more
core   +1 more source

Artemis Links ATM to G₂/M Checkpoint Recovery via Regulation of Cdk1-Cyclin B

Molecular and Cellular Biology, 2007
Liyi Geng, Xiaoshan Zhang, Shu Zheng, Randy J. Legerski   +3 more
openalex   +2 more sources

Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E

Cell Communication and Signaling, 2013
BackgroundSevere shortage of liver donors and hepatocytes highlights urgent requirement of extra-liver and stem cell source of hepatocytes for treating liver-related diseases.
Zhenzhen Zhang, Y. Gong, Ying Guo, Yanan Hai, Hao Yang, Shi Yang, Yang Liu, Meng Ma, Linhong Liu, Zheng Li, Wei-Qiang Gao, Zuping He   +11 more
semanticscholar   +1 more source

Cyclin D1 + large B-cell lymphoma with altered CCND1 and BCL-6 rearrangements: a diagnostic challenge

Biomarker Research, 2019
Background A subset of diffuse large B-cell lymphoma may show aberrant cyclin D1 expression, which may be confused with blastoid mantle cell lymphoma. These cases usually lack of CCND1 gene rearrangement.
Da Gao, Zach Liu
doaj   +1 more source

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]

, 2017
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman, Bronte, Catherine A. Vaughan, Frum, Lin, Luzhna, Olivier, Oren, Rebecca A. Frum, Shilpa Singh, Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Zeman, Zuazua-Villar   +14 more
core   +2 more sources

Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor

Nature Communications, 2012
Maturation/M-phase-promoting factor is the universal inducer of M-phase in eukaryotic cells. It is currently accepted that M-phase-promoting factor is identical to the kinase cyclin B–Cdk1. Here we show that cyclin B–Cdk1 and M-phase-promoting factor are
Masatoshi Hara, Yusuke Abe, Toshiaki Tanaka, Takayoshi Yamamoto, E. Okumura, T. Kishimoto   +5 more
semanticscholar   +1 more source

The potential role of As-sumo-1 in the embryonic diapause process and early embryo development of Artemia sinica.

PLoS ONE, 2014
During embryonic development of Artemia sinica, environmental stresses induce the embryo diapause phenomenon, required to resist apoptosis and regulate cell cycle activity.
Bing Chu, Feng Yao, Cheng Cheng, Yang Wu, Yanli Mei, Xuejie Li, Yan Liu, Peisheng Wang, Lin Hou, Xiangyang Zou   +9 more
doaj   +1 more source