Results 51 to 60 of about 470,056 (173)
Cell Cycling Models of Carcinogenesis: A Complex Systems Analysis [PDF]
arXiv, 2004 A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter ...
arxiv
Tumor suppressor and anti-inflammatory protein: an expanded view on insulin-degrading enzyme (IDE) [PDF]
arXiv, 2008 In 1994, I conjectured that insulin-degrading enzyme (IDE) acts as an inhibitor of malignant transformation by degrading insulin and thus preventing this major growth-stimulatory hormone from binding and thereby inactivating the retinoblastoma tumor suppressor protein (RB).
arxiv
Prognostic value of cyclin B in endometrial endometrioid adenocarcinoma
Tumor Biology, 2014 Cyclins are a group of cell cycle regulatory proteins. Cyclin B acts as an activator to cyclin-dependent kinase 1 (CDK1), a protein kinase essential for G2/M phase transition. Deregulation of cyclins has been linked to a number of malignant neoplasms, but the impact on clinicopathological parameters seems to be cancer-specific. Overexpression of cyclin
Markku Santala +4 more
openaire +2 more sources
Certain amplified genomic-DNA fragments (AGFs) may be involved in cell cycle progression and chloroquine is found to induce the production of cell-cycle-associated AGFs (CAGFs) in Plasmodium falciparum [PDF]
arXiv, 2015 It is well known that cyclins are a family of proteins that control cell-cycle progression by activating cyclin-dependent kinase. Based on our experimental results, we propose here a novel hypothesis that certain amplified genomic-DNA fragments (AGFs) may also be required for the cell cycle progression of eukaryotic cells and thus can be named as cell ...
arxiv
The cycline subalgebra of a Kumjian-Pask algebra [PDF]
Proc. Amer. Math. Soc. 145 (2017), no. 5, 1969-1980, 2016 Let $\Lambda$ be a row-finite higher-rank graph with no sources. We identify a maximal commutative subalgebra $\mathcal{M}$ inside the Kumjian-Pask algebra ${\rm KP}_R(\Lambda)$. We also prove a generalized Cuntz-Krieger uniqueness theorem for Kumjian-Pask algebras which says that a representation of ${\rm KP}_R(\Lambda)$ is injective if and only if it
arxiv
Prediction of repurposed drugs for treating lung injury in COVID-19 [PDF]
arXiv, 2020 Coronavirus disease (COVID-19) is an infectious disease discovered in 2019 and currently in outbreak across the world. Lung injury with severe respiratory failure is the leading cause of death in COVID-19, brought by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv
Periodic higher rank graphs revisited [PDF]
arXiv, 2014 Let $P$ be a finitely generated cancellative abelian monoid. A $P$-graph $\Lambda$ is a natural generalization of a higher rank graph. A pullback of $\Lambda$ is constructed by pulling it back over a given monoid morphism to $P$, while a pushout of $\Lambda$ is obtained by modding out its periodicity $\Per\Lambda$, which is deduced from a natural ...
arxiv
Is Cyclin D2 a Marker of B-CLL Cell Activation?
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2009 The most recent studies emphasize a link between B-cell proliferation in vivo and clinical outcome of B-cell chronic lymphocytic leukemia (B-CLL). The expression of cyclin D2 in B-CLL cells isolated from the peripheral blood of 27 untreated patients in relation to the apoptosis ratio both before and 72 h after culture in the absence of growth factors ...
Aleksandra Szteblich +6 more
openaire +2 more sources
Bifurcation in cell cycle dynamics regulated by p53 [PDF]
arXiv, 2014 We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases.
arxiv
Regulation and Function of Cyclin D2 in B Lymphocyte Subsets [PDF]
The Journal of Immunology, 2004 AbstractAbs produced by B lymphocytes play an essential role in humoral immunity against pathogens. This response is dependent upon the extent of genome replication, which in turn allows clonal expansion of Ag-specific B cell precursors. Thus, there is considerable interest in understanding how naive B cells commit to genome replication following Ag ...
openaire +3 more sources