Results 51 to 60 of about 327,465 (302)

PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas

Frontiers in Oncology, 2022
PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba, Shigeo Ohba, Yongjian Tang, Yongjian Tang, Tor-Christian Aase Johannessen, Tor-Christian Aase Johannessen, Joydeep Mukherjee   +6 more
doaj   +1 more source

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]

, 2014
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S., Jaiswal, H., Lindqvist, A., Müllers, E., Saurin, A.T.   +4 more
core   +4 more sources

Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma

Haematologica, 2009
In a subset of B-cell malignancies, the genes encoding members of the cyclin D familiy are juxtaposed to immunoglobulin loci through recurrent chromosomal translocations.
Inga Nagel, Takashi Akasaka, Wolfram Klapper, Stefan Gesk, Sebastian Böttcher, Matthias Ritgen, Lana Harder, Michael Kneba, Martin J.S. Dyer, Reiner Siebert   +9 more
doaj   +1 more source

Early transformation event from follicular lymphoma: our experience of four cases

Polish Journal of Pathology, 2022
Follicular lymphoma (FL) is a mature B-cell lymphoma that can transform into a more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation of FL occurs by
Anurag Mehta, Diksha Karki, Prathyusha Gudapati   +2 more
doaj   +1 more source

The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes [PDF]

, 2005
Exit from the mitotic cell cycle and initiation of cell differentiation frequently coincides with the onset of endoreduplication, a modified cell cycle during which DNA continues to be duplicated in the absence of mitosis. Although the mitotic cell cycle
Verkest, Aurine, de Oliveira Manes, Carmem-Lara, Vercruysse, Steven, Maes, Sara, Van Der Schueren, Els, Beeckman, Tom, Genschik, Pascal, Kuiper, Martin, Inzé, Dirk, De Veylder, Lieven   +9 more
core   +1 more source

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]

, 2019
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra, Kõivomägi, Mardo, Rubin, Seth M, Sage, Julien, Skotheim, Jan M, Tambo, Carrie S, Topacio, Benjamin R, Xie, Shicong, Zatulovskiy, Evgeny   +8 more
core  

A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. [PDF]

The EMBO Journal, 1993
Both cyclins A and B associate with and thereby activate cyclin-dependent protein kinases (cdks). We have investigated which component in the cyclin-cdk complex determines its substrate specificity. The A- and B-type cyclin-cdk complexes phosphorylated histone H1 and their cyclin subunits in an indistinguishable manner, irrespective of the catalytic ...
D S, Peeper, L L, Parker, M E, Ewen, M, Toebes, F L, Hall, M, Xu, A, Zantema, A J, van der Eb, H, Piwnica-Worms   +8 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Post-transcriptional regulation of cyclin A and B mRNAs by Bruno 1, Cup, and P-bodies

iScience
Summary: Cell cycle progression relies on tightly regulated Cyclin synthesis and degradation, with Cyclins A and B activating CDK1 to drive mitosis. Dysregulation of Cyclin levels is linked to tumorigenesis, underscoring the importance of studying cyclin
Livia V. Bayer, Samantha N. Milano, Harpreet Kaur, Zara Kumar, Diana P. Bratu   +4 more
doaj   +1 more source

Patterns of cyclin A and B1 immunostaining in papillary thyroid carcinoma

Annals of Agricultural and Environmental Medicine, 2015
[b]Introduction and objectives. [/b]Cyclin A, encoded by CCNA (cyclin A) gene with locus in chromosome 4q27, and cyclin B1, encoded by CCNB1 (cyclin B1) gene with locus in chromosome 5q12, are proteins that play a key role in the passage through the ...
Anna Cyniak-Magierska, Magdalena Stasiak, Maciej Naze, Marek Dedecjus, Jan Brzeziński, Andrzej Lewiński   +5 more
doaj   +1 more source